ArticleLearning & memory (Cold Spring Harbor, N.Y.)2014
Delay and trace fear conditioning in C57BL/6 and DBA/2 mice: issues of measurement and performance.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Rapamycin and Minocycline Treatment Does Not Rescue Behavioral and Molecular Changes Induced by Early-Life Seizures in Female Mice.NeuroSci · 2026Article
- Involvement of Cortical Associative Areas in Acquisition and Retrieval of Delayed and Traced Conditioned Fear in Mice.Bulletin of experimental biology and medicine · 2026Article
- Sex differences in avoidance behavior and cued threat memory dynamics in mice: Interactions between estrous cycle and genetic background.Hormones and behavior · 2023Article
- Behavioral and genetic architecture of fear conditioning and related phenotypes.Neurobiology of learning and memory · 2023Article
- Intermixed safety cues facilitate extinction retention in adult and adolescent mice.Physiology & behavior · 2023Article
- Sociability versus empathy in adolescent mice: Different or distinctive?Learning and motivation · 2023Article
- Impact of Mephedrone on Fear Memory in Adolescent Rats: Involvement of Matrix Metalloproteinase-9 (MMP-9) and N-Methyl-D-aspartate (NMDA) Receptor.International journal of molecular sciences · 2023Article
- Dysregulation ofLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Repetitive and Inflexible Active Coping and Addiction-like Neuroplasticity in Stressed Mice of a Helplessness-Resistant Inbred Strain.Behavioral sciences (Basel, Switzerland) · 2021Article
- Genetic background determines behavioral responses during fear conditioning.Neurobiology of learning and memory · 2021Article
- Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).The European journal of neuroscience · 2021Review
- Interactions Between Experience, Genotype and Sex in the Development of Individual Coping Strategies.Frontiers in behavioral neuroscience · 2021Article
- Preclinical testing of the ketogenic diet in fragile X mice.Neurochemistry international · 2020Article
- Behavioral and immunohistochemical characterization of rapid reconditioning following extinction of contextual fear.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Article
- Rapid reacquisition of contextual fear following extinction in mice: effects of amount of extinction, acute ethanol withdrawal, and ethanol intoxication.Psychopharmacology · 2019Article
- Sex-specific deficits in biochemical but not behavioral responses to delay fear conditioning in prenatal alcohol exposure mice.Neurobiology of learning and memory · 2018Article
- Cued fear memory generalization increases over time.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- A GluN2B-Selective NMDAR Antagonist Reverses Synapse Loss and Cognitive Impairment Produced by the HIV-1 Protein Tat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Germline Chd8 haploinsufficiency alters brain development in mouse.Nature neuroscience · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Strain comparison studies have been critical to the identification of novel genetic and molecular mechanisms in learning and memory. However, even within a single learning paradigm, the behavioral data for the same strain can vary greatly, making it difficult to form meaningful conclusions at both the behavioral and cellular level. In fear conditioning, there is a high level of variability across reports, especially regarding responses to the conditioned stimulus (CS). Here, we compare C57BL/6 and DBA/2 mice using delay fear conditioning, trace fear conditioning, and a nonassociative condition. Our data highlight both the significant strain differences apparent in these fear conditioning paradigms and the significant differences in conditioning type within each strain. We then compare our data to an extensive literature review of delay and trace fear conditioning in these two strains. Finally, we apply a number of commonly used baseline normalization approaches to compare how they alter the reported differences. Our findings highlight three major sources of variability in the fear conditioning literature: CS duration, number of CS presentations, and data normalization to baseline measures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.