ArticleReproductive sciences (Thousand Oaks, Calif.)2015
Endometrial CXCL13 expression is cycle regulated in humans and aberrantly expressed in humans and Rhesus macaques with endometriosis.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- The role of the CXC chemokine family in endometriosis research and its therapeutic potential.Journal of molecular histology · 2025Review
- Molecular Mechanisms of Endometriosis Revealed Using Omics Data.Biomedicines · 2023Review
- Challenges in Clinical Diagnosis and Management of Chronic Endometritis.Diagnostics (Basel, Switzerland) · 2022Review
- Targeted Nanoparticles with High Heating Efficiency for the Treatment of Endometriosis with Systemically Delivered Magnetic Hyperthermia.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Identification of Key Genes and Pathways associated with Endometriosis by Weighted Gene Co-expression Network Analysis.International journal of medical sciences · 2021Article
- mGAP: the macaque genotype and phenotype resource, a framework for accessing and interpreting macaque variant data, and identifying new models of human disease.BMC genomics · 2019Article
- Elevated serum chemokines are independently associated with both endometriosis and uranium exposure.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Increased levels of CCR7(lo)PD-1(hi) CXCR5Experimental and therapeutic medicine · 2017Article
- mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Human Decidual Stromal Cells as a Component of the Implantation Niche and a Modulator of Maternal Immunity.Journal of pregnancy · 2016Review
- Article
- Animal Models to Study Placental Development and Function throughout Normal and Dysfunctional Human Pregnancy.Seminars in reproductive medicine · 2016Review
- Reproductive sciences on the forefront of endometriosis news.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
C-X-C ligand 13 (CXCL13), a regulator of mucosal immunity, is secreted by human endometrial epithelium and may be involved in embryo implantation. However, cyclic expression of human endometrial CXCL13 in health and disease is not well studied. This study examines cycle stage-specific endometrial CXCL13 expression in normal humans when compared to those with biopsy-confirmed, stage 1 to 4 endometriosis using real-time reverse transcriptase, real-time polymerase chain reaction and immunohistochemistry. Eutopic endometrial CXCL13 expression was also compared between normal, control Rhesus macaques, and macaques with advanced endometriosis. In healthy women, CXLC13 messenger RNA expression was minimal in the proliferative phase and maximal in the secretory phase. However, in the presence of endometriosis, proliferative-phase endometrial expression markedly increased in both humans and rhesus subjects (P < .05). The cross-species and cross-stage concordance suggests a pathophysiologic role for CXCL13 in endometriosis and its use as a biomarker for disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.