ArticleJournal of the renin-angiotensin-aldosterone system : JRAAS2015
The value of losartan suppression test in the confirmatory diagnosis of primary aldosteronism in patients over 50 years old.
Article in Journal of the renin-angiotensin-aldosterone system : JRAAS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Performance of Confirmatory Tests for Diagnosing Primary Aldosteronism: a Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2022Pooled it
- Comparison of saline infusion test and captopril challenge test in the diagnosis of Chinese with primary aldosteronism in different age groups.Frontiers in endocrinology · 2024Observational
- The Value of Different Single or Combined Indexes of the Captopril Challenge Test in the Diagnosis of Primary Aldosteronism.Frontiers in endocrinology · 2021Article
- Diagnostic Role of Captopril Challenge Test in Korean Subjects with High Aldosterone-to-Renin Ratios.Endocrinology and metabolism (Seoul, Korea) · 2016Article
- Potential effects of age on screening for primary aldosteronism.Journal of human hypertension · 2016Article
- Evaluation of oral telmisartan administration as a suppression test for diagnosis of primary hyperaldosteronism in cats.Journal of veterinary internal medicineArticle
- Prospective evaluation of a telmisartan suppression test as a diagnostic tool for primary hyperaldosteronism in cats.Journal of veterinary internal medicineArticle
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThe diagnosis of primary aldosteronism (PA) among the older-aged population has posed a crucial challenge. Among patients over 50 years old, this trial assessed comparability of the performance of two PA diagnostic tests: losartan and captopril suppression tests.
methodsA post-hoc subgroup analysis from a prospective cohort was conducted by the TAIPAI (Taiwan Primary Aldosteronism Investigation) group between July 2003 and July 2006. Of the 160 patients in the cohort, 60 patients over 50 years old received captopril and losartan tests to confirm PA.
resultsAmong the 60 patients over 50 years old, 31 patients had PA confirmed by standardized protocol. The area under the receiver-operating characteristic (ROC) curve for post-captopril aldosterone was significantly less than that for post-losartan plasma aldosterone concentration (PAC) (0.87 vs 0.94, p=0.02). Using the aldosterone-renin ratio (ARR)>35 with PAC>10 ng/dl, the specificity was 82.76% vs 93.1% and the sensitivity was 77.42% vs 87.10% for the captopril and losartan tests, respectively. The equivalence between the two tests were confirmed by the exact McNemar's test (p=1.0).
conclusionThe losartan test showed comparable accuracy to confirm PA. Verification of this "elderly-friendly" confirmatory test will be the first step to prepare a specific diagnostic model of PA for the older-aged population.
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