ArticleDiabetologia2014
Fermentable fibres condition colon microbiota and promote diabetogenesis in NOD mice.
Article in Diabetologia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach.Microbiology spectrum · 2022Trial
- The Impact of Essential Amino Acids on the Gut Microbiota of Broiler Chickens.Microorganisms · 2024Review
- Pectin from Fruit- and Berry-Juice Production by-Products: Determination of Physicochemical, Antioxidant and Rheological Properties.Foods (Basel, Switzerland) · 2023Article
- Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice.Experimental and therapeutic medicine · 2023Article
- Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms.Frontiers in endocrinology · 2020Review
- Targeting gut microbiota and barrier function with prebiotics to alleviate autoimmune manifestations in NOD mice.Diabetologia · 2019Article
- Dissecting the role of the gut microbiota and diet on visceral fat mass accumulation.Scientific reports · 2019Article
- Overall Dietary Quality Relates to Gut Microbiota Diversity and Abundance.International journal of molecular sciences · 2019Article
- Role of intestinal microbiota and metabolites on gut homeostasis and human diseases.BMC immunology · 2017Review
- Article
- Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of parents and their offspring in a rodent model.Gut microbes · 2016Article
- Cutting Edge: Commensal Microbiota Has Disparate Effects on Manifestations of Polyglandular Autoimmune Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The role of the intestinal microbiota in type 1 diabetes mellitus.Nature reviews. Endocrinology · 2016Review
- On the role of gut bacteria and infant diet in the development of autoimmunity for type 1 diabetes. Reply to Hänninen ALM and Toivonen RK [letter].Diabetologia · 2015Article
- On the role of gut bacteria and infant diet in the development of autoimmunity for type 1 diabetes.Diabetologia · 2015Article
- Microbial community profiles of the colon from steers differing in feed efficiency.SpringerPlus · 2015Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisGut microbiota (GM) and diet both appear to be important in the pathogenesis of type 1 diabetes. Fermentable fibres (FFs), of which there is an ample supply in natural, diabetes-promoting diets, are used by GM as a source of energy. Our aim was to determine whether FFs modify GM and diabetes incidence in the NOD mouse.
methodsFemale NOD mice were weaned to a semisynthetic diet and the effects of FF supplementation on diabetes incidence and insulitis were evaluated. Real-time quantitative PCR was employed to determine the effects imposed to gene transcripts in the colon and lymph nodes. Changes to GM were analysed by next-generation sequencing.
resultsNOD mice fed semisynthetic diets free from FFs were largely protected from diabetes while semisynthetic diets supplemented with the FFs pectin and xylan (PX) resulted in higher diabetes incidence. Semisynthetic diet free from FFs altered GM composition significantly; addition of PX changed the composition of the GM towards that found in natural-diet-fed mice and increased production of FF-derived short-chain fatty acid metabolites in the colon. The highly diabetogenic natural diet was associated with expression of proinflammatory and stress-related genes in the colon, while the semisynthetic diet free from FFs promoted Il4, Il22, Tgfβ and Foxp3 transcripts in the colon and/or pancreatic lymph node. PX in the same diet counteracted these effects and promoted stress-related IL-18 activation in gut epithelial cells. 16S RNA sequencing revealed each diet to give rise to its particular GM composition, with different Firmicutes to Bacteroidetes ratios, and enrichment of mucin-degrading Ruminococcaceae following diabetes-protective FF-free diet. CONCLUSIONS/
interpretationFFs condition microbiota, affect colon homeostasis and are important components of natural, diabetes-promoting diets in NOD mice.
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