ArticleNeuro-oncology2015
Localizing seizure-susceptible brain regions associated with low-grade gliomas using voxel-based lesion-symptom mapping.
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Article in Neuro-oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 1 of them a synthesis that pooled it.
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141citing papers in PubMed, 1 pooled it
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Who cites it
141 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Correlation between glioma location and preoperative seizures: a systematic review and meta-analysis.Neurosurgical review · 2019Pooled it
- Microstructural changes of white matter fiber tracts induced by insular glioma revealed by tract-based spatial statistics and automatic fiber quantification.Scientific reports · 2022Trial
- [Journal of neuro-oncology · 2026Article
- MS4A4A promotes macrophages M2 polarization via NF-κB /JAK-STAT6 axis, resulting GBM malignant progression.Oncogene · 2026Article
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- Uncovering G Protein-Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis.Annals of clinical and translational neurology · 2026Article
- mCell death and differentiation · 2026Article
- PHF23-Related Prognostic Signature Modulates Immune Microenvironment and Promotes Tumor Malignancy in Glioma.International journal of molecular sciences · 2026Article
- Establishment of a novel gene panel for prognosis assessment in patients with lower grade glioma.Medicine · 2026Article
- Integrating multiomics to elucidate the role of chromatin remodeling in glioma and the antitumor mechanisms and therapeutic potential of targeting LMNA.Frontiers in immunology · 2026Article
- Brain regions associated with frequent occurrences of seizures related to low-grade gliomas: a voxel-level evidence.Frontiers in human neuroscience · 2026Article
- Extending voxel-based lesion mapping to neurosurgical oncology: applications in intracranial meningiomas.Frontiers in oncology · 2026Article
- Integrative Transcriptomic and Perturbagen Analyses Reveal Sex-Specific Molecular Signatures Across Glioma Subtypes.Cancers · 2025Article
- Targeting Pan-Cancer Stemness: Core Regulatory lncRNAs as Novel Therapeutic Vulnerabilities.International journal of molecular sciences · 2025Article
- A Prognostic Neuromodulation-Related Gene Signature Identifies Immunomodulation and Tumour-Associated Hallmarks in Glioblastoma.Biomedicines · 2025Article
- Integrative multi-omics analysis identifies AEBP1 and EFEMP2 as key regulators of immune heterogeneity and therapeutic response in glioblastoma.Discover oncology · 2025Article
- The HBP Pathway Inhibitor FR054 Enhances Temozolomide Sensitivity in Glioblastoma Cells by Promoting Ferroptosis and Inhibiting O-GlcNAcylation.CNS neuroscience & therapeutics · 2025Article
- A comprehensive analysis of transcription factors identified TCF3 as a prognostic target for glioma.Scientific reports · 2025Article
- Antiseizure medications for preventing a first seizure in adults with a brain tumour.The Cochrane database of systematic reviews · 2025Article
- Machine learning unravels the mysteries of glioma typing and treatment.Biochemistry and biophysics reports · 2025Article
81 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Yinyan WangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Tianyi QianBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Gan YouBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Xiaoxia PengBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Clark ChenBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Yongping YouBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Kun YaoBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Chenxing WuBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Jun MaBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Zhiyi ShaBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Sonya WangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Tao JiangBeijing Neurosurgical Institute, Capital Medical University, Beijing, China (Y.W., T.J.); Department of Neurosurgery (Y.W., G.Y., T.J.); Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (J.M.); Siemens Healthcare, MR Collaboration NE Asia, Beijing, China (T.Q.); Department of Epidemiology and Biostatistics, School of Public Health and Family Medicine, Capital Medical University, Beijing, China (X.P.); Department of Neurosurgery (C.C.); Department of Pediatric Neurology, University of California, San Diego, California (S.W.); Department of Neurosurgery, Nanjing Medical University, The First Affiliated Hospital, Nanjing, China (Y.Y.); Department of Neurosurgery, Beijing Sanbo Hospital, Capital Medical University, Beijing, China (K.Y., C.W.); Department of Neurology, Medical School, University of Minnesota, Minneapolis, Minnesota (Z.S.).
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients afflicted with low-grade glioma (LGG) frequently suffer from seizures. The mechanisms of seizure initiation in these patients remain poorly understood. Tumor location has been correlated with seizure initiation. However, these correlative studies relied on dichotomized data analysis based on arbitrary lobe assignments. As a result, the lesion-symptom correlation may be incorrectly interpreted. Here, we present the first study that used a voxel-wise quantitative lesion analysis to investigate the spatial correlation between tumor location and seizure susceptibility.
methodsWe collected the medical records and magnetic resonance images of 410 LGG patients. The dataset was divided into a discovery set and a validation set. A voxel-based lesion-symptom correlative analysis was performed to determine whether tumor location was associated with seizure risk and could be related to the specific type of seizure.
resultsFor all seizure types, increased seizure risks were identified for LGGs that involved the left premotor area. The LGGs that involved the posterior portion of the left inferior and middle frontal gyrus were associated with increased risk of simple partial seizures. LGGs that involved the right temporal-insular region were associated with an increased risk of complex partial seizures. LGGs that involved the left premotor area were more likely to be associated with seizures that generalize. These correlations were consistently observed in both the discovery and the validation datasets.
conclusionsOur quantitative neuroimaging analyses support the concept that the anatomic location of an LGG is a contributing factor in tumor-related seizure.
Indexed as
AdolescentAdultAgedBrainBrain MappingBrain NeoplasmsFemaleGliomaHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesSeizuresYoung Adultlesion-symptom mappinglow-grade gliomaseizure
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