ArticleThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2014
Functional connectivity architecture of the human brain: not all the same.
Article in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05282277 (Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Effects of Estradiol on Neural and Molecular Response to Rewards in Perimenopausal-Onset Anhedonia and Psychosis
Who cites it
29 citing papers in PubMed.
- Measuring the Impacts of Urbanicity and Different Exposome Factors on Human Brain through Exposure Network Mapping.Neuroscience bulletin · 2026Article
- Clinical Application of Resting-State Functional MRI for Individualized Localization of Core Language Areas in Patients with Drug-Resistant Epilepsy: An Observational Study.Neuropsychiatric disease and treatment · 2026Article
- Exploring risk and protective urban environmental factors on mental health through exposure network mapping.Research square · 2025Article
- Resting-state fMRI reveals brain functional alterations linked to balance disorders in vestibular migraine patients.Scientific reports · 2025Article
- Individual connectivity-based parcellations reflect functional properties of human auditory cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Individual differences in the neural architecture in semantic processing.Scientific reports · 2024Article
- Functional connectivity analyses of individual hippocampal subregions in major depressive disorder with electroconvulsive therapy.Psychoradiology · 2024Article
- Predicting executive functioning from functional brain connectivity: network specificity and age effects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Automated optimization of TMS coil placement for personalized functional network engagement.Neuron · 2022Article
- Group-level comparison of brain connectivity networks.BMC medical research methodology · 2022Article
- Functional individual variability development of the neonatal brain.Brain structure & function · 2022Article
- Personalized fMRI Delineates Functional Regions Preserved within Brain Tumors.Annals of neurology · 2022Article
- Functional connectivity within glioblastoma impacts overall survival.Neuro-oncology · 2021Article
- Structural Brain Architectures Match Intrinsic Functional Networks and Vary across Domains: A Study from 15 000+ Individuals.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Deep Brain Stimulation Initiative: Toward Innovative Technology, New Disease Indications, and Approaches to Current and Future Clinical Challenges in Neuromodulation Therapy.Frontiers in neurology · 2020Review
- Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease.Human brain mapping · 2019Article
- Development and Emergence of Individual Variability in the Functional Connectivity Architecture of the Preterm Human Brain.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Neural and behavioral signature of human social perception.Scientific reports · 2019Article
- Performing group-level functional image analyses based on homologous functional regions mapped in individuals.PLoS biology · 2019Article
- Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids.APL bioengineering · 2018Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Imaging studies suggest that individual differences in cognition and behavior might relate to differences in brain connectivity, particularly in the higher order association regions. Understanding the extent to which two brains can differ is crucial in clinical and basic neuroscience research. Here we highlight two major sources of variance that contribute to intersubject variability in connectivity measurements but are often mixed: the spatial distribution variability and the connection strength variability. We then offer a hypothesis about how the cortical surface expansion during human evolution may have led to remarkable intersubject variability in brain connectivity. We propose that a series of changes in connectivity architecture occurred in response to the pressure for processing efficiency in the enlarged brain. These changes not only distinguish us from our evolutionary ancestors, but also enable each individual to develop more uniquely. This hypothesis may gain support from the significant spatial correlations among evolutionary cortical expansion, the density of long-range connections, hemispheric functional specialization, and intersubject variability in connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.