ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2014
Associative transcriptomics study dissects the genetic architecture of seed glucosinolate content in Brassica napus.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 83 citations in OpenAlex.
- Glucosinolates inInternational journal of molecular sciences · 2026Review
- Quantitative Trait Loci Identification and Candidate Genes Characterization for Indole-3-Carbinol Content in Seedlings ofInternational journal of molecular sciences · 2025Article
- A naturally occurring promoter variation ofFrontiers in plant science · 2025Article
- Pathogen lifestyle determines host genetic signature of quantitative disease resistance loci in oilseed rape (Brassica napus).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genome- and Transcriptome-wide Association Studies to Discover Candidate Genes for Diverse Root Phenotypes in Cultivated Rice.Rice (New York, N.Y.) · 2023Article
- Article
- Natural variation and artificial selection at the BnaC2.MYB28 locus modulate Brassica napus seed glucosinolate.Plant physiology · 2023Article
- Further insight into decreases in seed glucosinolate content based on QTL mapping and RNA-seq in Brassica napus L.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Mapping-by-Sequencing Reveals Genomic Regions Associated with Seed Quality Parameters inGenes · 2022Article
- Genome- and transcriptome-wide association studies reveal the genetic basis and the breeding history of seed glucosinolate content in Brassica napus.Plant biotechnology journal · 2022Article
- Genomic signatures of vegetable and oilseed allopolyploid Brassica juncea and genetic loci controlling the accumulation of glucosinolates.Plant biotechnology journal · 2021Article
- Validation of a novel associative transcriptomics pipeline in Brassica oleracea: identifying candidates for vernalisation response.BMC genomics · 2021Article
- Parallel analysis of global garlic gene expression and alliin content following leaf wounding.BMC plant biology · 2021Article
- Genomics Armed With Diversity Leads the Way inFrontiers in genetics · 2021Review
- Dissection of genetic architecture for glucosinolate accumulations in leaves and seeds of Brassica napus by genome-wide association study.Plant biotechnology journal · 2020Article
- Fine mapping and candidate gene analysis of a seed glucosinolate content QTL, qGSL-C2, in rapeseed (Brassica napus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020Article
- Association Mapping of Seed Quality Traits Under Varying Conditions of Nitrogen Application inFrontiers in genetics · 2020Article
- AFrontiers in plant science · 2020Article
- Genetic architecture of glucosinolate variation in Brassica napus.Journal of plant physiology · 2019Article
- Transcriptome-wide association study and eQTL analysis to assess the genetic basis of bulb-yield traits in garlic (Allium sativum).BMC genomics · 2019Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Breeding new varieties with low seed glucosinolate (GS) concentrations has long been a prime target in Brassica napus. In this study, a novel association mapping methodology termed 'associative transcriptomics' (AT) was applied to a panel of 101 B. napus lines to define genetic regions and also candidate genes controlling total seed GS contents. Over 100,000 informative single-nucleotide polymorphisms (SNPs) and gene expression markers (GEMs) were developed for AT analysis, which led to the identification of 10 SNP and 7 GEM association peaks. Within these peaks, 26 genes were inferred to be involved in GS biosynthesis. A weighted gene co-expression network analysis provided additional 40 candidate genes. The transcript abundance in leaves of two candidate genes, BnaA.GTR2a located on chromosome A2 and BnaC.HAG3b on C9, was correlated with seed GS content, explaining 18.8 and 16.8% of phenotypic variation, respectively. Resequencing of genomic regions revealed six new SNPs in BnaA.GTR2a and four insertions or deletions in BnaC.HAG3b. These deletion polymorphisms were then successfully converted into polymerase chain reaction-based diagnostic markers that can, due to high linkage disequilibrium observed in these regions of the genome, be used for marker-assisted breeding for low seed GS lines.
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