ArticleJournal of the Royal Society, Interface2014
High coverage fluid-phase floating lipid bilayers supported by ω-thiolipid self-assembled monolayers.
Article in Journal of the Royal Society, Interface, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
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- Exploiting neutron scattering contrast variation in biological membrane studies.Biophysics reviews · 2022Review
- Surface-tethered planar membranes containing the β-barrel assembly machinery: a platform for investigating bacterial outer membrane protein folding.Biophysical journal · 2021Article
- Large scale model lipid membrane movement induced by a cation switch.Journal of colloid and interface science · 2021Article
- Studying the surfaces of bacteria using neutron scattering: finding new openings for antibiotics.Biochemical Society transactions · 2020Review
- Physical Properties of Bacterial Outer Membrane Models: Neutron Reflectometry & Molecular Simulation.Biophysical journal · 2019Article
- Antibiotic resistance and host immune evasion inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Supramolecular electrode assemblies for bioelectrochemistry.Chemical communications (Cambridge, England) · 2017Review
- An Accurate In Vitro Model of theAngewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2015Article
- An accurate in vitro model of the E. coli envelope.Angewandte Chemie (International ed. in English) · 2015Article
- Effect of divalent cation removal on the structure of gram-negative bacterial outer membrane models.Langmuir : the ACS journal of surfaces and colloids · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Large area lipid bilayers, on solid surfaces, are useful in physical studies of biological membranes. It is advantageous to minimize the interactions of these bilayers with the substrate and this can be achieved via the formation of a floating supported bilayer (FSB) upon either a surface bound phospholipid bilayer or monolayer. The FSB's independence is enabled by the continuous water layer (greater than 15 Å) that remains between the two. However, previous FSBs have had limited stability and low density. Here, we demonstrate by surface plasmon resonance and neutron reflectivity, the formation of a complete self-assembled monolayer (SAM) on gold surfaces by a synthetic phosphatidylcholine bearing a thiol group at the end of one fatty acyl chain. Furthermore, a very dense FSB (more than 96%) of saturated phosphatidylcholine can be formed on this SAM by sequential Langmuir-Blodgett and Langmuir-Schaefer procedures. Neutron reflectivity used both isotopic and magnetic contrast to enhance the accuracy of the data fits. This system offers the means to study transmembrane proteins, membrane potential effects (using the gold as an electrode) and even model bacterial outer membranes. Using unsaturated phosphatidylcholines, which have previously failed to form stable FSBs, we achieved a coverage of 73%.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.