ArticleEuropean journal of nutrition2015
Physiologically achievable doses of resveratrol enhance 3T3-L1 adipocyte differentiation.
Article in European journal of nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Effect of resveratrol on metabolic syndrome components: A systematic review and meta-analysis.Reviews in endocrine & metabolic disorders · 2019Pooled it
- Effects of Resveratrol on Browning and Insulin Signaling in Primary Murine Adipocytes: Modulation by Sex and Diabetic Status.Nutrients · 2025Article
- Review
- Anti-Adipogenic Activity of Secondary Metabolites Isolated fromInternational journal of molecular sciences · 2023Article
- Plasma levels of sirtuin-1 in patients with cerebrovascular stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- The Role of Resveratrol Administration in Human Obesity.International journal of molecular sciences · 2021Review
- Review
- Tanshinol alleviates impaired bone formation by inhibiting adipogenesis via KLF15/PPARγ2 signaling in GIO rats.Acta pharmacologica Sinica · 2018Article
- Resveratrol liposomes and lipid nanocarriers: Comparison of characteristics and inducing browning of white adipocytes.Colloids and surfaces. B, Biointerfaces · 2018Article
- Resveratrol inhibits obesity-associated adipose tissue dysfunction and tumor growth in a mouse model of postmenopausal claudin-low breast cancer.Molecular carcinogenesis · 2018Article
- Resveratrol attenuates triglyceride accumulation associated with upregulation of Sirt1 and lipoprotein lipase in 3T3-L1 adipocytes.Molecular genetics and metabolism reports · 2017Article
- Molecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of Flavonoids.International journal of molecular sciences · 2016Review
- Combinations of bio-active dietary constituents affect human white adipocyte function in-vitro.Nutrition & metabolism · 2016Article
- Review
- Doses of Quercetin in the Range of Serum Concentrations Exert Delipidating Effects in 3T3-L1 Preadipocytes by Acting on Different Stages of Adipogenesis, but Not in Mature Adipocytes.Oxidative medicine and cellular longevity · 2015Article
- Resveratrol: anti-obesity mechanisms of action.Molecules (Basel, Switzerland) · 2014Review
- Resveratrol ameliorates high glucose and high-fat/sucrose diet-induced vascular hyperpermeability involving Cav-1/eNOS regulation.PloS one · 2014Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeResveratrol is a natural polyphenolic stilbene widely found in grapes, berries, and other plants. Caloric restriction-like effects of resveratrol have been associated with suppressive and apoptotic effects on adipocyte differentiation in vitro when used at high doses (≥ 20 µM), which may not be achievable in vivo. The aim of this study was to investigate the effects of resveratrol at physiologically achievable low doses (1 and 10 μM) on 3T3-L1 adipocyte differentiation.
methods3T3-L1 preadipocytes were differentiated into adipocytes using a modified adipogenic cocktail in the presence or absence of resveratrol. Differentiation was determined by lipid accumulation and mRNA expression of marker genes. Activation of glucocorticoid receptor (GR) and peroxisome proliferator-activated receptor γ (PPARγ) was determined by transcription factor-mediated reporter assays and mRNA expression of target genes. Protein samples were collected for the study of AMPK activation.
resultsResveratrol at physiologically achievable doses (1 and 10 µM) significantly enhanced 3T3-L1 adipocyte differentiation although the effect was less pronounced compared with that achieved under optimal differentiation cocktail in vitro. Resveratrol (1-50 µM) dose dependently activated or synergized with the synthetic ligand or adipogenic treatment to activate GR and PPARγ. However, resveratrol induced cell death when used at doses above 10 µM in differentiating cells.
conclusionsOur results report for the first time that resveratrol at physiologically achievable doses (1 and 10 µM) enhances 3T3-L1 adipocyte differentiation, which supports the emerging paradigm that enhanced adipocyte differentiation may be associated with caloric restriction-like metabolic effects for resveratrol.
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