ArticleCritical care (London, England)2014
Immune derangement occurs in patients with H7N9 avian influenza.
Article in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Should We Interfere with the Interleukin-6 Receptor During COVID-19: What Do We Know So Far?Drugs · 2023Review
- Protective Intranasal Immunization Against Influenza Virus in Infant Mice Is Dependent on IL-6.Frontiers in immunology · 2020Article
- Article
- A new reassortment of influenza A (H7N9) virus causing human infection in Beijing, 2014.Scientific reports · 2016Article
- Severe Infection With Avian Influenza A Virus is Associated With Delayed Immune Recovery in Survivors.Medicine · 2016Article
- Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro.Biochemical and biophysical research communications · 2015Article
- The dysfunctional host response to influenza A H7N9: a potential treatment option?Critical care (London, England) · 2014Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCurrently, little is known about the immunological characteristics of patients with avian influenza A (H7N9) virus infection.
methodsThe numbers and percentages of peripheral blood immune cells were measured in 27 patients with laboratory-confirmed H7N9 virus infection and 30 healthy controls (HCs). The functional phenotypes of T cells and monocytes, as well as serum cytokine levels, were analyzed by flow cytometry.
resultsThere were 19 patients (70.4%) with acute respiratory distress syndrome, 13 (48.1%) with secondary respiratory infection, 20 (74%) with systemic inflammatory response syndrome (SIRS; defined as having at least two concurrent SIRS components), 18 (66.7%) with lymphocytopenia and 11 (40.7%) with reduced numbers of monocytes. In comparison with levels in the HCs, the levels of serum interleukin 6 (IL-6), IL-8 and IL-10 and the percentages of CD38+ or Tim-3+ T cells were significantly increased. However, the percentages of human leukocyte antigen-DR + and Tim-3+ monocytes were significantly decreased in patients compared with HCs.
conclusionsPatients with avian H7N9 virus infection display profound SIRS concomitantly with an anti-inflammatory response, which may be associated with the rapid progression of and high mortality associated with this novel viral disease.
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