Binding of fullerenes and nanotubes to MscL.

Tamsyn A Hilder, Pietro Ridone, Yoshitaka Nakayama, Boris Martinac, Shin-Ho Chung

Abstract read

In one paragraph

Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tamsyn A HilderComputational Biophysics Group, Research School of Biology, Australian National University, ACT 0200, Australia.

Pietro RidoneMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, NSW 2010, Australia.

Yoshitaka NakayamaMolecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, NSW 2010, Australia.

Boris Martinac1] Molecular Cardiology and Biophysics Division, Victor Chang Cardiac Research Institute, NSW 2010, Australia [2] St Vincent's Clinical School, The University of New South Wales, Victoria St, St Vincent's Hospital Darlinghurst NSW 2010, Australia.

Shin-Ho ChungComputational Biophysics Group, Research School of Biology, Australian National University, ACT 0200, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-drug resistance is becoming an increasing problem in the treatment of bacterial infections and diseases. The mechanosensitive channel of large conductance (MscL) is highly conserved among prokaryotes. Evidence suggests that a pharmacological agent that can affect the gating of, or block the current through, MscL has significant potential as a new class of antimicrobial compound capable of targeting a range of pathogenic bacteria with minimal side-effects to infected patients. Using molecular dynamics we examine the binding of fullerenes and nanotubes to MscL and demonstrate that both are stable within the MscL pore. We predict that fullerenes will attenuate the flow of ions through MscL by reducing the pore volume available to water and ions, but nanotubes will prevent pore closure resulting in a permanently open pore. Moreover, we confirm experimentally that it is possible to attenuate the flow of ions through MscL using a C60-γ cyclodextrin complex.

Indexed as

Molecular Dynamics SimulationBinding SitesBoron CompoundsEscherichia coli ProteinsFullerenesIon ChannelsNanotubes, CarbonProtein BindingBoron Compoundsboron nitrideEscherichia coli ProteinsFullerenesIon ChannelsMscL protein, E coliNanotubes, Carbon

Identifiers

PMID25030051

DOI10.1038/srep05609

PMCPMC4101527

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-SA

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.