Trial reportLeukemia & lymphoma2015
Skeletal, neuromuscular and fitness impairments among children with newly diagnosed acute lymphoblastic leukemia.
Trial report in Leukemia & lymphoma, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Total XV - Total Therapy Study XV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia
Rehabilitation Including Structured Active Play for Preschoolers With Cancer.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Physical capacity in children and adolescents with newly diagnosed cancer: A systematic review and meta-analysis.Pediatric blood & cancer · 2024Pooled it
- Physical and functional performance assessment in pediatric oncology: a systematic review.Pediatric research · 2022Pooled it
- Gross motor function, functional level, physical performance, and muscle strength in preschool children newly diagnosed with cancer: Data from the RePlay trial.European journal of pediatrics · 2026Trial
- Evaluating the feasibility of a rehabilitation intervention including physical activity as structured active play for preschoolers diagnosed with cancer during the first 6 months of treatment-a study based on data from the RePlay trial.European journal of pediatrics · 2025Trial
- Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies.Scientific reports · 2020Trial
- Effects of a home-exercise programme in childhood survivors of acute lymphoblastic leukaemia on physical fitness and physical functioning: results of a randomised clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Myosteatosis in adolescents and young adults treated for acute lymphoblastic leukemia.Leukemia & lymphoma · 2019Trial
- Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia.Pediatric blood & cancer · 2018Trial
- Effect of Low-Magnitude, High-Frequency Mechanical Stimulation on BMD Among Young Childhood Cancer Survivors: A Randomized Clinical Trial.JAMA oncology · 2016Trial
- Monitoring Steps and Heart Rate Using a Withings Smartwatch in Children and Adolescents With Cancer: Validation Study.JMIR cancer · 2026Article
- Moving Forward Together: A Protocol to Co-Adapt and Scale a Videoconference-Delivered Physical Activity Intervention for Children and Adolescents Diagnosed With Cancer or Blood Disorders in British Columbia, Ontario, and the Maritime Provinces.JMIR research protocols · 2026Article
- Association of neuropathy, sarcopenia and physical function in acute lymphoblastic leukemia survivors with chemotherapy alone.Journal of cancer survivorship : research and practice · 2026Article
- Low intensity vibration with zoledronate reduces musculoskeletal weakness and adiposity in estrogen deprived female mice.Nature communications · 2026Article
- Feasibility, uptake, and exploratory outcomes of an individualized exercise program in pediatric oncology: a prospective single-center pilot study.Frontiers in pediatrics · 2026Article
- Precision-based exercise protocols for children with cancer: a methodological approach from the European FORTEe research project.Frontiers in pediatrics · 2026Article
- Muscle fitness and physical function in children and adolescents with newly diagnosed cancer.Frontiers in pediatrics · 2026Article
- Identifying Key Factors in Adherence and Dropouts in Active Physiotherapy in Children with Acute Leukemia: A Systematic Review with Meta-Analysis and Meta-Regression.Healthcare (Basel, Switzerland) · 2025Review
- Development of Functional Abilities Assessment in Paediatric Oncology (FAAP-O) Scale for Children and Adolescents Affected by Cancer.Children (Basel, Switzerland) · 2025Article
- Safety of cardiorespiratory and muscle fitness assessment in two children with leukemia during early chemotherapy.Journal of pediatric rehabilitation medicine · 2025Article
- Establishing consensus on defining the physically vulnerable child with cancer: a protocol for an international Delphi approach.BMJ paediatrics open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
This study describes skeletal, neuromuscular and fitness impairments among 109 children (median age 10 [range 4-18] years, 65.1% male, 63.3% white) with acute lymphoblastic leukemia (ALL). Outcomes were measured 7-10 days after diagnosis and compared to age- and sex-specific expected values. Associations between function and health-related quality of life (HRQL) were evaluated with logistic regression. Children with ALL had sub-optimal bone mineral density (BMD) Z-score/height (mean ± standard error: - 0.53 ± 0.16 vs. 0.00 ± 0.14, p < 0.01), body mass index percentile (57.6 ± 3.15 vs. 50.0 ± 3.27%, p = 0.02), quadriceps strength (201.9 ± 8.3 vs. 236.1 ± 5.4 N, p < 0.01), 6 min walk distance (385.0 ± 13.1 vs. 628.2 ± 7.1 m, p < 0.001) and Bruininks-Oseretsky Test of Motor Proficiency scores (23 ± 2.5 vs. 50 ± 3.4%, p < 0.01). Quadriceps weakness was associated with a 20.9-fold (95% confidence interval 2.5-173.3) increase in poor physical HRQL. Children with newly diagnosed ALL have weakness and poor endurance and may benefit from early rehabilitation that includes strengthening and aerobic conditioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.