ArticlePloS one2014
Time and frequency-dependent modulation of local field potential synchronization by deep brain stimulation.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Cortico-striatal beta oscillations as a reward-related signal.Cognitive, affective & behavioral neuroscience · 2024Article
- Role and contributions of women in revolutionizing neurosurgery.World neurosurgery: X · 2024Review
- High-Frequency Local Field Potential Oscillations for Pigeons in Effective Turning.Animals : an open access journal from MDPI · 2024Article
- Women in Neuromodulation: Innovative Contributions to Stereotactic and Functional Neurosurgery.Frontiers in human neuroscience · 2021Review
- Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.Brain : a journal of neurology · 2020Article
- A novel low-cost electrode for recording the local field potential of freely moving rat's brain.Translational neuroscience · 2020Article
- Use of intraoperative local field potential spectral analysis to differentiate basal ganglia structures in Parkinson's disease patients.Physiological reports · 2017Article
- Higher-order power harmonics of pulsed electrical stimulation modulates corticospinal contribution of peripheral nerve stimulation.Scientific reports · 2017Article
- Robust modulation of arousal regulation, performance, and frontostriatal activity through central thalamic deep brain stimulation in healthy nonhuman primates.Journal of neurophysiology · 2016Article
- Anti-kindling Induced by Two-Stage Coordinated Reset Stimulation with Weak Onset Intensity.Frontiers in computational neuroscience · 2016Article
- Cholinergic mechanisms of high-frequency stimulation in entopeduncular nucleus.Journal of neurophysiology · 2016Article
- Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation.Journal of neurophysiology · 2015Review
- Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
High-frequency electrical stimulation of specific brain structures, known as deep brain stimulation (DBS), is an effective treatment for movement disorders, but mechanisms of action remain unclear. We examined the time-dependent effects of DBS applied to the entopeduncular nucleus (EP), the rat homolog of the internal globus pallidus, a target used for treatment of both dystonia and Parkinson's disease (PD). We performed simultaneous multi-site local field potential (LFP) recordings in urethane-anesthetized rats to assess the effects of high-frequency (HF, 130 Hz; clinically effective), low-frequency (LF, 15 Hz; ineffective) and sham DBS delivered to EP. LFP activity was recorded from dorsal striatum (STR), ventroanterior thalamus (VA), primary motor cortex (M1), and the stimulation site in EP. Spontaneous and acute stimulation-induced LFP oscillation power and functional connectivity were assessed at baseline, and after 30, 60, and 90 minutes of stimulation. HF EP DBS produced widespread alterations in spontaneous and stimulus-induced LFP oscillations, with some effects similar across regions and others occurring in a region- and frequency band-specific manner. Many of these changes evolved over time. HF EP DBS produced an initial transient reduction in power in the low beta band in M1 and STR; however, phase synchronization between these regions in the low beta band was markedly suppressed at all time points. DBS also enhanced low gamma synchronization throughout the circuit. With sustained stimulation, there were significant reductions in low beta synchronization between M1-VA and STR-VA, and increases in power within regions in the faster frequency bands. HF DBS also suppressed the ability of acute EP stimulation to induce beta oscillations in all regions along the circuit. This dynamic pattern of synchronizing and desynchronizing effects of EP DBS suggests a complex modulation of activity along cortico-BG-thalamic circuits underlying the therapeutic effects of GPi DBS for conditions such as PD and dystonia.
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