Trial reportThe Journal of clinical endocrinology and metabolism2014
Dietary sodium restriction decreases insulin secretion without affecting insulin sensitivity in humans.
Trial report in The Journal of clinical endocrinology and metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Dynamic Adjustments of Parenteral Support in Early Adult Intestinal Failure-Essential Role of Sodium.Nutrients · 2020Trial
- Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial.The Journal of clinical endocrinology and metabolism · 2015Trial
- The role of dietary salt in metabolism and energy balance: Insights beyond cardiovascular disease.Diabetes, obesity & metabolism · 2023Review
- Association of renin and aldosterone with glucose metabolism in a Western European population: the KORA F4/FF4 study.BMJ open diabetes research & care · 2022Article
- The association between normal serum sodium levels and bone turnover in patients with type 2 diabetes.Frontiers in endocrinology · 2022Article
- High-fat and high-sodium diet induces metabolic dysfunction in the absence of obesity.Obesity (Silver Spring, Md.) · 2021Article
- Treatment of Primary Aldosteronism Increases Plasma Epoxyeicosatrienoic Acids.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Primary Aldosteronism Decreases Insulin Secretion and Increases Insulin Clearance in Humans.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Article
- Hyperinsulinemia and Insulin Resistance in Dopamine β-Hydroxylase Deficiency.The Journal of clinical endocrinology and metabolism · 2017Article
- Sodium-glucose cotransporter-2 inhibition and acidosis in patients with type 2 diabetes: a review of US FDA data and possible conclusions.International journal of nephrology and renovascular disease · 2017Article
- Differential Effects of Two Antialdosterone Agents on Glycemic Control.Endocrinology · 2016Article
- Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects.Metabolism: clinical and experimental · 2016Article
- Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association.Circulation. Cardiovascular genetics · 2016Review
- Activation of the Endogenous Renin-Angiotensin-Aldosterone System or Aldosterone Administration Increases Urinary Exosomal Sodium Channel Excretion.Journal of the American Society of Nephrology : JASN · 2016Article
- Sodium and Its Role in Cardiovascular Disease - The Debate Continues.Frontiers in endocrinology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
contextInterruption of the renin-angiotensin-aldosterone system prevents incident diabetes in high-risk individuals, although the mechanism remains unclear.
objectiveTo test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system or exogenous aldosterone impairs insulin secretion in humans.
designWe conducted a randomized, blinded crossover study of aldosterone vs vehicle and compared the effects of a low-sodium versus a high-sodium diet.
settingAcademic clinical research center.
participantsHealthy, nondiabetic, normotensive volunteers.
interventionsInfusion of exogenous aldosterone (0.7 μg/kg/h for 12.5 h) or vehicle during low or high sodium intake. Low sodium (20 mmol/d; n = 12) vs high sodium (160 mmol/d; n = 17) intake for 5-7 days.
main outcome measuresChange in acute insulin secretory response assessed during hyperglycemic clamps while in sodium balance during a low-sodium vs high-sodium diet during aldosterone vs vehicle.
resultsA low-sodium diet increased endogenous aldosterone and plasma renin activity, and acute glucose-stimulated insulin (-16.0 ± 5.6%; P = .007) and C-peptide responses (-21.8 ± 8.4%; P = .014) were decreased, whereas the insulin sensitivity index was unchanged (-1.0 ± 10.7%; P = .98). Aldosterone infusion did not affect the acute insulin response (+1.8 ± 4.8%; P = .72) or insulin sensitivity index (+2.0 ± 8.8%; P = .78). Systolic blood pressure and serum potassium were similar during low and high sodium intake and during aldosterone infusion.
conclusionsLow dietary sodium intake reduces insulin secretion in humans, independent of insulin sensitivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.