Evidence map›Paper›PMID 25029231›Full record

Trial reportBone marrow transplantation2014

Malnutrition in patients with chronic GVHD.

C W Bassim, H Fassil, M Dobbin, S M Steinberg, K Baird, K Cole, G Joe, L E Comis, S A Mitchell, L Grkovic and 7 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Bone marrow transplantation, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  7. Review
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  9. Review
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  17. Review
  18. Article
  19. Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2018
    Article
  20. Biology of chronic graft-World journal of transplantation · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

C W BassimClinical Research Center, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
H FassilExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
M DobbinNutrition Department, National Institutes of Health, Bethesda, MD, USA.
S M SteinbergBiostatistics and Data Management Section, Office of the Clinical Director, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
K BairdPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
K ColeExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
G JoeRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, USA.
L E ComisRehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, USA.
S A MitchellOutcomes Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
L Grkovic1] Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA [2] Division of Hematology, Department of Internal Medicine, Clinical Hospital Center Zagreb, Zagreb, Croatia.
D EdwardsClinical Research Center, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
J W MaysClinical Research Center, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
E W CowenDermatology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
D Pulanic1] Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA [2] Division of Hematology, Department of Internal Medicine, Clinical Hospital Center Zagreb, Zagreb, Croatia.
K M WilliamsExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
R E GressExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
S Z PavleticExperimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
National Institutes of Health · USNational Cancer Institute · USCenter for Cancer Research · USNational Institute of Dental and Craniofacial Research · US

Funding

NIDCR DIR Clinical TrainingZIEDE000727 · NIDCR · NATIONAL INSTITUTE OF DENTAL & CRANIOFACIAL RESEARCH · PI MAYS, JACQUELINE · 2009 to 2025
$6.8M
Chronic graft-versus-host diseaseZIABC011549 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI COWEN, EDWARD · 2014 to 2021
$5.2M
Intramural NIH HHS Z99 DE999999
6 · The paper itself

Abstract

Malnutrition is a known complication of chronic GVHD (cGVHD), but has not been well described in the context of organ-specific manifestations and the recent National Institutes of Health (NIH) criteria. Here, 210 cGVHD patients were analyzed, in a cross-sectional study design, for demographics, transplant-related history, clinical assessments, symptoms, function, quality-of-life, laboratory values and survival in order to determine their associations with nutritional status. Most patients had long-standing, moderate or severe cGVHD and had failed many lines of therapy. Twenty-nine percent (60/210) of subjects were malnourished, using the subjective Patient-Generated Subjective Global Assessment (PG-SGA) questionnaire and evaluation. No demographic or transplant characteristics were associated with malnutrition; cGVHD of the lungs, gastrointestinal (GI) tract and mouth, NIH global score, cGVHD symptoms, worse functioning, low albumin, poorer survival and low BMI were associated with malnutrition. A predictive model was developed from all variables of significance: cGVHD of the lungs, GI tract, mouth and BMI accurately predicted 84.2% of malnourished patients as well as 87.2% of well-nourished patients. The PG-SGA questionnaire may be a useful tool in diagnosing nutritional deficits in cGVHD patients undergoing one-time evaluations. Longitudinal prospective studies should assess the utility of nutritional support interventions in cGVHD.

Indexed as

AdolescentAdultAgedFemaleGraft vs Host DiseaseHumansMaleMalnutritionMiddle AgedQuality of LifeSeverity of Illness IndexYoung Adult

Identifiers

PMID25029231
PMCPMC5535789
OpenAlexW2010392843

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.