ArticleCritical care (London, England)2014
Elevated malondialdehyde levels in sepsis - something to 'stress' about?
Article in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04169412 (Resuscitation Failure, Protein Carbonyl and Receptor Interacting Protein Kinase 3 as Mortality Predictor in Septic Patient), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Resuscitation Failure, Protein Carbonyl and Receptor Interacting Protein Kinase 3 as Mortality Predictor in Septic Patient
Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Protective Effect of Barberry (Berberis vulgaris L.) Extract on Oxidative Stress and Behavioral Changes in Toxicity Induced by Diazinon in the Brain Tissue of Male Rats.Brain and behavior · 2026Article
- Evaluation of oxidative stress in ill neonatal foals: a preliminary study.Journal of veterinary internal medicine · 2026Article
- Royal jelly attenuates DMBA induced preneoplastic lesions in rat mammary gland and Skin.Scientific reports · 2026Article
- Coelenterazine alleviates sepsis-associated acute kidney injury by inhibiting ferroptosis via the USP14-NCOA4 pathway.Translational andrology and urology · 2025Article
- Pre-existing adipose tissue signaling profile related to obesity determines disease outcome of COVID-19: addressing obesity should be a priority for future pandemic preparedness.Frontiers in endocrinology · 2025Article
- Glucans: A Therapeutic Alternative for Sepsis Treatment.Journal of immunology research · 2024Review
- Potential Role of Glutathione Antioxidant Pathways in the Pathophysiology and Adjunct Treatment of Psychiatric Disorders.Clinics and practice · 2023Review
- Genes regulating oxidative-inflammatory response in circulating monocytes and neutrophils in septic syndrome.Biologia futura · 2023Article
- Synbiotics and Their Antioxidant Properties, Mechanisms, and Benefits on Human and Animal Health: A Narrative Review.Biomolecules · 2022Review
- Newly synthesized chitosan-nanoparticles attenuate carbendazim hepatorenal toxicity in rats via activation of Nrf2/HO1 signalling pathway.Scientific reports · 2022Article
- Oxidant/Antioxidant Status Is Impaired in Sepsis and Is Related to Anti-Apoptotic, Inflammatory, and Innate Immunity Alterations.Antioxidants (Basel, Switzerland) · 2022Article
- Usefulness of ischemia-modified albumin in the diagnosis of sepsis/septic shock in the emergency department.Clinical and experimental emergency medicine · 2020Article
- PEGylated Bilirubin-coated Iron Oxide Nanoparticles as a Biosensor for Magnetic Relaxation Switching-based ROS Detection in Whole Blood.Theranostics · 2020Article
- Evaluation of the effect of intraperitoneal etanercept administration on oxidative stress and inflammation indicators in the kidney and blood of experimental sepsis-induced rats.Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
- Article
- Salivary Gland Extract fromCells · 2018Article
- Markers of Oxidative Stress and Clinical Outcome in Critically ill Septic Patients: A Preliminary Study from North India.Journal of clinical and diagnostic research : JCDR · 2016Article
- Multiple Biomarkers to Assess the Pathophysiological State in Critically Ill Patients with Sepsis.Indian journal of clinical biochemistry : IJCB · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Oxidative stress has been postulated as a mechanism of organ dysfunction - and thus a potential therapeutic target - in sepsis. Lorente and colleagues report increased serum levels of malondialdehyde, a biomarker of oxidative stress-induced lipid peroxidation, in adults with severe sepsis, particularly in non-survivors. While survivors exhibited a decrease in serum malondialdehyde over time, the elevation was sustained in non-survivors. These findings suggest that there is increased oxidative stress in sepsis and that membrane lipids in particular are targeted by free radical species. Further study is required to validate the utility of malondialdehyde as a prognostic biomarker in sepsis and to determine a role for antioxidant therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.