ArticleCoronary artery disease2014
Microvascular endothelial dysfunction predicts the development of erectile dysfunction in men with coronary atherosclerosis without critical stenoses.
Article in Coronary artery disease, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies.Frontiers in cardiovascular medicine · 2025Review
- Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding.European stroke journal · 2023Article
- A study of the relationship between brachial artery vasodilation and platelet/lymphocyte ratio in diabetic patients with coronary atherosclerosis.Journal of clinical laboratory analysis · 2023Article
- Coronary microvascular dysfunction is an independent predictor of developing cancer in patients with non-obstructive coronary artery disease.European journal of preventive cardiology · 2023Article
- Critical role of the coronary microvasculature in heart disease: From pathologic driving force to "innocent" bystander.American heart journal plus : cardiology research and practice · 2022Article
- The spectrum and systemic associations of microvascular dysfunction in the heart and other organs.Nature cardiovascular research · 2022Review
- Chronic liver diseases and erectile dysfunction.Frontiers in public health · 2022Review
- Relationship between the Severity of Coronary Artery Disease and Catheter-Associated Urethral Stricture in Patients with Acute Coronary Syndrome.The journal of Tehran Heart Center · 2020Article
- [Prevalence and severity of erectile dysfunction in patients with type 2 diabetes in the Department of Urology at the University Hospital Center Hassan II, Fez, Morocco: a cross-sectional study of 96 cases].The Pan African medical journal · 2020Article
- Triglyceride and Triglyceride/ HDL (High Density Lipoprotein) Ratio Predict Major Adverse Cardiovascular Outcomes in Women With Non-Obstructive Coronary Artery Disease.Journal of the American Heart Association · 2019Article
- Erectile dysfunction severity as a predictor of left main and/or three-vessel disease in acute coronary syndrome patients.Indian heart journal · 2018Article
- Association between Fragmented QRS and Left Ventricular Systolic Function in Patients with Erectile Dysfunction.Acta Cardiologica Sinica · 2018Article
- Uric Acid Is Associated With Inflammation, Coronary Microvascular Dysfunction, and Adverse Outcomes in Postmenopausal Women.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Coronary microvascular dysfunction: sex-specific risk, diagnosis, and therapy.Nature reviews. Cardiology · 2015Review
- Association of erectile dysfunction with depression in patients with chronic viral hepatitis.World journal of gastroenterology · 2015Observational
- Risk of erectile dysfunction in transfusion-naive thalassemia men: a nationwide population-based retrospective cohort study.Medicine · 2015Article
- Severity of erectile dysfunction is highly correlated with the syntax score in patients undergoing coronariography.International braz j urol : official journal of the Brazilian Society of UrologyArticle
- Erectile dysfunction is associated with subclinical carotid vascular disease in young men lacking widely-known risk factors.Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundErectile dysfunction (ED) is associated with an increased risk for cardiovascular disease, stroke, and all-cause mortality, independent of conventional cardiovascular risk factors. Coronary endothelial dysfunction is independently associated with ED in men with early coronary atherosclerosis. We aimed to investigate whether coronary microvascular dysfunction predicts development of ED in patients presenting with coronary atherosclerosis without critical stenoses. PATIENTS AND
methodsCoronary microvascular function was evaluated in 130 men with coronary atherosclerosis without critical stenoses by administration of intracoronary acetylcholine at the time of diagnostic study. After a mean follow-up of 8.4 years, patients were assessed for the development of ED by administration of a questionnaire.
resultsIn all, 68 (50%) men had microvascular endothelial dysfunction at baseline; 35 (51%) men with microvascular endothelial dysfunction developed ED on follow-up compared with 19 (31%) men without microvascular endothelial dysfunction. Men who developed ED had a lower coronary blood flow response (% [INCREMENT]CBF) compared with men who did not develop ED, with mean±SD of 25.4±71.3 versus 81.7±120 (P=0.003). In univariate analysis, microvascular endothelial dysfunction was a predictor for the development of ED, with relative risk of 2.4 (1.2-4.9) (P=0.016). In multivariate logistic regression adjusting for traditional cardiovascular risk factors (age, hypertension, hyperlipidemia, diabetes, vascular disease, and family history of coronary artery disease), only microvascular endothelial dysfunction (P=0.027) and age (P=0.044) remained significant predictors of development of ED.
conclusionCoronary microvascular dysfunction is a predictor of the development of ED in men with coronary atherosclerosis without critical stenoses. This study underscores the systemic involvement of the endothelial function in vascular disease.
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