ArticleBiophysical journal2014
Collective cell movement promotes synchronization of coupled genetic oscillators.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 52 citations in OpenAlex.
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- A review of dynamical systems approaches for the detection of chaotic attractors in cancer networks.Patterns (New York, N.Y.) · 2021Review
- From local resynchronization to global pattern recovery in the zebrafish segmentation clock.eLife · 2021Article
- Role of cell polarity dynamics and motility in pattern formation due to contact-dependent signalling.Journal of the Royal Society, Interface · 2021Article
- Bioelectrical control of positional information in development and regeneration: A review of conceptual and computational advances.Progress in biophysics and molecular biology · 2018Review
- Collective gradient sensing and chemotaxis: modeling and recent developments.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Review
- A framework for quantification and physical modeling of cell mixing applied to oscillator synchronization in vertebrate somitogenesis.Biology open · 2017Article
- Is the Epididymis a Series of Organs Placed Side By Side?Biology of reproduction · 2016Review
- Delay decomposition approach to [Formula: see text] filtering analysis of genetic oscillator networks with time-varying delays.Cognitive neurodynamics · 2016Article
- Dynamics of Cell Ensembles on Adhesive Micropatterns: Bridging the Gap between Single Cell Spreading and Collective Cell Migration.PLoS computational biology · 2016Article
- The tissue mechanics of vertebrate body elongation and segmentation.Current opinion in genetics & development · 2015Review
- Salient features of otoacoustic emissions are common across tetrapod groups and suggest shared properties of generation mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Collective cell movement is a crucial component of embryonic development. Intercellular interactions regulate collective cell movement by allowing cells to transfer information. A key question is how collective cell movement itself influences information flow produced in tissues by intercellular interactions. Here, we study the effect of collective cell movement on the synchronization of locally coupled genetic oscillators. This study is motivated by the segmentation clock in zebrafish somitogenesis, where short-range correlated movement of cells has been observed. We describe the segmentation clock tissue by a Voronoi diagram, cell movement by the force balance of self-propelled and repulsive forces between cells, the dynamics of the direction of self-propelled motion, and the synchronization of genetic oscillators by locally coupled phase oscillators. We find that movement with a correlation length of about 2 ∼ 3 cell diameters is optimal for the synchronization of coupled oscillators. Quantification of cell mixing reveals that this short-range correlation of cell movement allows cells to exchange neighbors most efficiently. Moreover, short-range correlated movement strongly destabilizes nonuniform spatial phase patterns, further promoting global synchronization. Our theoretical results suggest that collective cell movement may enhance the synchronization of the segmentation clock in zebrafish somitogenesis. More generally, collective cell movement may promote information flow in tissues by enhancing cell mixing and destabilizing spurious patterns.
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