Evidence map›Paper›PMID 25028622›Full record

ReviewKidney international supplements2011

The complexity of the cardio-renal link: taxonomy, syndromes, and diseases.

Carmine Zoccali, David Goldsmith, Rajiv Agarwal, Peter J Blankestijn, Danilo Fliser, Andrzej Wiecek, Gultekin Suleymanlar, Alberto Ortiz, Ziad Massy, Adrian Covic and 6 more

Abstract readReview
In one paragraph

Review in Kidney international supplements, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Arterial Stiffness in the Heart Disease of CKD.Journal of the American Society of Nephrology : JASN · 2019
    Review
  9. The systemic nature of CKD.Nature reviews. Nephrology · 2017
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Carmine ZoccaliNephrology, Dialysis and Transplantation Unit and CNR-IBIM Clinical Epidemiology and Pathophysiology of Renal Diseases and Hypertension , Reggio Calabria, Italy.
David GoldsmithRenal Unit, Guy's and St Thomas' NHS Foundation Hospital, King's Health Partners , London, UK.
Rajiv AgarwalIndiana University and VAMC , Indianapolis, Indiana, USA.
Peter J BlankestijnDepartment of Nephrology, University Medical Center , Utrecht, The Netherlands.
Danilo FliserDepartment of Internal Medicine IV, Saarland University Medical Centre , Homburg/Saar, Germany.
Andrzej WiecekDivision of Internal Medicine and Nephrology, Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia , Katowice, Poland.
Gultekin SuleymanlarNephrology Division, Department of Medicine, Akdeniz University Medical School , Antalya, Turkey.
Alberto OrtizFundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo , Madrid, Spain.
Ziad MassyINSERM ERI-12 (EA 4292) , Amiens, France ; Amiens University Hospital and the Jules Verne University of Picardie , Amiens, France.
Adrian CovicClinic of Nephrology, C.I. Parhon University Hospital, Gr. T. Popa University of Medicine and Pharmacy , Iasi, Romania.
Alberto Martinez-CastelaoHospital Universitario de Bellvitge, IDIBELL, L'Hospitalet de Llobregat , Barcelona, Spain.
Kitty J JagerERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam , Amsterdam, The Netherlands.
Friedo W DekkerDepartment of Clinical Epidemiology, Leiden University Medical Center , Leiden, The Netherlands.
Bengt LindholmDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet , Stockholm, Sweden.
Gerard LondonINSERM U970, Hôpital Européen Georges Pompidou , Paris, France.
for EUropean REnal and CArdiovascular Medicine working group of the European Renal Association–European Dialysis and Transplant Association (ERA–EDTA)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bidirectional mechanisms exist that link diseases affecting the heart and kidney. This link is complex and remains poorly understood; therefore, charting the shared territory of cardiovascular (CV) and renal medicine poses major problems. Until now, no convincing rationale for delineating new syndromes existed. The multiple connections of the arterial system and the heart and kidney with other systems, from energy and protein balance to the musculoskeletal, clearly require special focus and rigorous framing. Nephrologists have yet to fully understand why the application of dialysis has had only limited success in halting the parallel burdens of CV and non-CV death in patients with end-stage renal disease. Cardiologists, intensivists, and nephrologists alike should settle whether and when extracorporeal ultrafiltration benefits patients with decompensated heart failure. These sparse but interconnected themes spanning from the basic science-clinical transition phase to clinical science, epidemiology, and medical technology already form the basis for the young discipline of 'CV and renal medicine'.

Indexed as

cardio-renalcardiovascular riskCKDdeathESRDprogression of CKD

Identifiers

PMID25028622
PMCPMC4089616

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.