ArticleEvidence-based complementary and alternative medicine : eCAM2014
The effect of 1,8-cineole inhalation on preoperative anxiety: a randomized clinical trial.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Music therapy integrated virtual reality education for preoperative anxiety in gynecological surgery.Scientific reports · 2026Trial
- Smelling Wellness: Associations Between Botanic Garden Scentscapes and Human Health Gains.International journal of environmental research and public health · 2026Trial
- Alleviating effect of lavender (Lavandula angustifolia) and its major components on postherpetic pain: a randomized blinded controlled trial.BMC complementary medicine and therapies · 2024Trial
- 1,8-Cineole (Eucalyptol) in Neurodegeneration: From Pharmacological Mechanisms to Therapeutic Applications.Cells · 2026Review
- Eucalyptol Attenuates Lead-Induced Anxiety-like Behaviors by Suppressing Oxidative Stress and Neuroinflammation, Modulating SIRT1/NF-κB Signaling, and Upregulating BDNF Expression.Biological trace element research · 2025Article
- Article
- Identification of CD8 T-cell dysfunction associated with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID and treatment with a nebulized antioxidant/anti-pathogen agent in a retrospective case series.Brain, behavior, & immunity - health · 2024Article
- Foliar application of various biostimulants produces contrasting response on yield, essential oil and chemical properties of organically grown sage (Frontiers in plant science · 2024Article
- Thermodynamic Behavior of (2-Propanol + 1,8-Cineole) Mixtures: Isothermal Vapor-Liquid Equilibria, Densities, Enthalpies of Mixing, and Modeling.International journal of molecular sciences · 2023Article
- A new drug formula for pneumonia and severe seasonal flu; a promising drug for eradicate COVID19.Materials today. Proceedings · 2023Article
- Article
- Nanofiber-Based Odor-Free Medical Mask Fabrication Using Polyvinyl Butyral and Eucalyptus Anti Odor Agent.Polymers · 2022Article
- Aromas Influencing the GABAergic System.Molecules (Basel, Switzerland) · 2022Review
- Non-pharmacologic Approaches in Preoperative Anxiety, a Comprehensive Review.Frontiers in public health · 2022Review
- 3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds.Pharmaceutics · 2021Article
- Fleeting Beauty-The World of Plant Fragrances and Their Application.Molecules (Basel, Switzerland) · 2021Review
- Impact of Lavender on Pain and Anxiety Levels Associated With Spine Procedures.Ochsner journal · 2021Article
- Inhalation Administration of the Bicyclic Ethers 1,8- and 1,4-cineole Prevent Anxiety and Depressive-Like Behaviours in Mice.Molecules (Basel, Switzerland) · 2020Article
- Role of phytochemicals as nutraceuticals for cognitive functions affected in ageing.British journal of pharmacology · 2020Review
- The Therapeutic Potential of the Essential Oil ofFrontiers in pharmacology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effect of inhalation of eucalyptus oil and its constituents on anxiety in patients before selective nerve root block (SNRB). This study was a randomized controlled trial carried out in 62 patients before SNRB. The patients were randomized to inhale limonene, 1,8-cineole, or eucalyptus oil, each at concentrations of 1% vol/vol in almond oil or almond oil (control). Anxiety-visual analog scale (A-VAS), state-trait anxiety inventory (STAI), profile of mood states (POMS), pain-visual analog scale (P-VAS), blood pressure, and pulse rate were measured before and after inhalation prior to SNRB. Measures of anxiety, including A-VAS (P < 0.001), STAI (P = 0.005), and POMS (P < 0.001), were significantly lower in 1,8-cineole than in the control group and significantly greater in 1,8-cineole than in the eucalyptus group in A-VAS. P-VAS was significantly lower after than before inhalation of limonene, 1,8-cineole, and eucalyptus, despite having no significant difference in the four groups compared with control group. 1,8-Cineole, a major constituent of eucalyptus, was effective in decreasing anxiety before SNRB. The present findings suggest that inhalation of 1,8-cineole may be used to relieve anxiety before, during, and after various operations, in addition to SNRB.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.