ArticleDiabetes2014
Increased intraretinal PO2 in short-term diabetic rats.
Article in Diabetes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Imaging Hypoxia in the Diabetic Retina: A Potential Early-Detection Imaging Biomarker Before Detectable Retinopathy in Diabetes.Diabetes · 2026Article
- Quantifying retinal oxygenation and metabolism by phosphorescence lifetime imaging.Experimental eye research · 2025Review
- Article
- Review
- Photoreceptor cells and RPE contribute to the development of diabetic retinopathy.Progress in retinal and eye research · 2021Review
- Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography.Scientific reports · 2021Article
- Diabetic photoreceptors: Mechanisms underlying changes in structure and function.Visual neuroscience · 2020Review
- Retinal Physiology and Circulation: Effect of Diabetes.Comprehensive Physiology · 2020Review
- Diabetes Alters pH Control in Rat Retina.Investigative ophthalmology & visual science · 2019Article
- Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice.Journal of biomedical optics · 2018Article
- Retinal oxygen: from animals to humans.Progress in retinal and eye research · 2017Review
- Retinal oximetry in humans using visible-light optical coherence tomography [Invited].Biomedical optics express · 2017Article
- Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice.Investigative ophthalmology & visual science · 2016Article
- Development of diabetes-induced acidosis in the rat retina.Experimental eye research · 2016Article
- MRI of rod cell compartment-specific function in disease and treatment in vivo.Progress in retinal and eye research · 2016Review
- Light adaptation does not prevent early retinal abnormalities in diabetic rats.Scientific reports · 2016Article
- The effect of intravitreal vascular endothelial growth factor on inner retinal oxygen delivery and metabolism in rats.Experimental eye research · 2016Article
- Hypoxia and Dark Adaptation in Diabetic Retinopathy: Interactions, Consequences, and Therapy.Current diabetes reports · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In diabetic retinopathy, neovascularization is hypothesized to develop due to hypoxia in the retina. However, evidence for retinal hypoxia is limited, and the progressive changes in oxygenation are unknown. The objective of this study was to determine if retinal hypoxia occurs early in the development of diabetes. Intraretinal oxygen (PO2) profiles were recorded with oxygen-sensitive microelectrodes in control and diabetic Long-Evans rats at 4 and 12 weeks after induction of diabetes. Diabetes did not affect oxygen consumption in the photoreceptors in either dark or light adaptation. Oxygenation of the inner retina was not affected after 4 weeks of diabetes, although vascular endothelial growth factor levels increased. At 12 weeks, average inner retinal PO2, normalized to choriocapillaris PO2, was higher in diabetic rats than in age-matched controls, which was opposite to what was expected. Thus retinal hypoxia is not a condition of early diabetes in rat retina. Increased inner retinal PO2 may occur because oxygen consumption decreases in the inner retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.