Trial reportCirculation. Cardiovascular genetics2014
Genome-wide linkage and regional association study of blood pressure response to the cold pressor test in Han Chinese: the genetic epidemiology network of salt sensitivity study.
Registry-linked trialAbstract readClinical Trial
In one paragraph
Trial report in Circulation. Cardiovascular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00721721 (Genetic Epidemiology Network of Salt Sensitivity), which is not on this map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology Network of Salt Sensitivity
Who cites it
5 citing papers in PubMed.
- Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas.Nature genetics · 2025Article
- Admixture mapping identifies genetic regions associated with blood pressure phenotypes in African Americans.PloS one · 2020Article
- TheBiology open · 2018Article
- Genomics of Cardiovascular Measures of Autonomic Tone.Journal of cardiovascular pharmacology · 2018Review
- Genetic variation in the alphaThe pharmacogenomics journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Xueli YangFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Dongfeng GuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.). gudongfeng@vip.sina.com tkelly@tulane.edu.
Jiang HeFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
James E HixsonFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Dabeeru C RaoFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Fanghong LuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Jianjun MuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Cashell E JaquishFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Jing ChenFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Jianfeng HuangFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Lawrence C ShimminFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Treva K RiceFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Jichun ChenFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Xigui WuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Depei LiuFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.).
Tanika N KellyFrom the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (X.Y., J.H., J.C., T.N.K.); State Key Laboratory of Cardiovascular Disease, Department of Epidemiology and Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases (X.Y., D.G., J.H., J.C., X.W.) and National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences (D.L.), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Department of Epidemiology, University of Texas School of Public Health, Houston (J.E.H., L.C.S.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R., T.K.R.); Institute of Basic Medicine, Shandong Academy of Medical Sciences, Shandong, China (F.L.); Department of Cardiology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Shaanxi, China (J.M.); and Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, MD (C.E.J.). gudongfeng@vip.sina.com tkelly@tulane.edu.
Funding
Genetic Epidemiology of Blood Pressure InterventionU01HL072507 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2002 to 2008
$7.6MFamily-Based Genome-wide Association Study for Salt-Sensitivity of Blood PressureR01HL090682 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2008 to 2011
$2.8MSodium Sensitivity and Risk of HypertensionR01HL087263 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI HE, JIANG · 2007 to 2011
$2.8MResearch Training in Gene-Environment Interaction in ChinaD43TW009107 · FIC · TULANE UNIVERSITY OF LOUISIANA · PI GU, DONGFENG, HE, JIANG · 2012 to 2016
$1.1MFIC NIH HHS D43 TW009107NHLBI NIH HHS R01 HL087263NHLBI NIH HHS R01HL087263NHLBI NIH HHS R01 HL090682NHLBI NIH HHS R01HL090682NHLBI NIH HHS U01 HL072507NHLBI NIH HHS U01HL072507
Abstract
backgroundBlood pressure (BP) response to cold pressor test (CPT) is associated with increased risk of cardiovascular disease. We performed a genome-wide linkage scan and regional association analysis to identify genetic determinants of BP response to CPT. METHODS AND
resultsA total of 1961 Chinese participants completed the CPT. Multipoint quantitative trait linkage analysis was performed, followed by single-marker and gene-based analyses of variants in promising linkage regions (logarithm of odds ≥2). A suggestive linkage signal was identified for systolic BP response to CPT at 20p13 to 20p12.3, with a maximum multipoint logarithm of odds score of 2.37. On the basis of regional association analysis with 1351 single nucleotide polymorphisms in the linkage region, we found that marker rs2326373 at 20p13 was significantly associated with mean arterial pressure responses to CPT (P=8.8×10(-6)) after false discovery rate adjustment for multiple comparisons. A similar trend was also observed for systolic BP response (P=0.03) and diastolic BP response (P=4.6×10(-5)). Results of gene-based analyses showed that variants in genes MCM8 and SLC23A2 were associated with systolic BP response to CPT (P=4.0×10(-5) and 2.7×10(-4), respectively), and variants in genes MCM8 and STK35 were associated with mean arterial pressure response to CPT (P=1.5×10(-5) and 5.0×10(-5), respectively).
conclusionsWithin a suggestive linkage region on chromosome 20, we identified a novel variant associated with BP responses to CPT. We also found gene-based associations of MCM8, SLC23A2, and STK35 in this region. Additional work is warranted to confirm these findings. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov; Unique identifier: NCT00721721.
Indexed as
AdolescentAdultAsian PeopleBlood PressureChinaChromosome MappingChromosomes, Human, Pair 20Cold TemperatureDemographyFemaleGenetic LinkageGenome-Wide Association StudyHumansHypertensionMaleMiddle AgedMCM8 protein, humanMinichromosome Maintenance ProteinsNuclear ProteinsProtein KinasesProtein Serine-Threonine KinasesSLC23A2 protein, humanSodium-Coupled Vitamin C TransportersSodium, DietarySTK35 protein, humanblood pressuregenetic association studieslinkage mapping
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NCT00721721ClinicalTrials.gov
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