ArticleLearning & memory (Cold Spring Harbor, N.Y.)2014
Contralateral disconnection of the rat prelimbic cortex and dorsomedial striatum impairs cue-guided behavioral switching.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- The effects of prelimbic inhibition on time-based intervention and impulsive choice.Behavioural brain research · 2027Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Age-related changes of dopamine D1 and D2 receptors expression in parvalbumin-positive cells of the orbitofrontal and prelimbic cortices of mice.Frontiers in neuroscience · 2024Article
- Exercise alters cortico-basal ganglia network metabolic connectivity: a mesoscopic level analysis informed by anatomic parcellation defined in the mouse brain connectome.Brain structure & function · 2023Article
- The Partial MACS chemical neuroscience · 2023Article
- Exploration behavior after reversals is predicted by STN-GPe synaptic plasticity in a basal ganglia model.iScience · 2023Article
- Article
- Medial prefrontal cortex lesions disrupt prepotent action selection signals in dorsomedial striatum.Current biology : CB · 2022Article
- Distinct Medial Orbitofrontal-Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A mind in motion: Exercise improves cognitive flexibility, impulsivity and alters dopamine receptor gene expression in a Parkinsonian rat model.Current research in neurobiology · 2022Article
- Chemogenetics Reveal an Anterior Cingulate-Thalamic Pathway for Attending to Task-Relevant Information.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Place vs. Response Learning: History, Controversy, and Neurobiology.Frontiers in behavioral neuroscience · 2020Article
- Dorsomedial prefrontal cortex neurons encode nicotine-cue associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- An Integrated Model of Action Selection: Distinct Modes of Cortical Control of Striatal Decision Making.Annual review of psychology · 2019Article
- Inhibiting gustatory thalamus or medial amygdala has opposing effects on taste neophobia.Neurobiology of learning and memory · 2018Article
- The effects of amygdala and cortical inactivation on taste neophobia.Neurobiology of learning and memory · 2018Article
- Prefrontal Corticostriatal Disconnection Blocks the Acquisition of Goal-Directed Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Complex Nature of Hippocampal-Striatal Interactions in Spatial Navigation.Frontiers in human neuroscience · 2018Article
- Control of behavioral flexibility by the lateral habenula.Pharmacology, biochemistry, and behavior · 2017Review
- Interactions between medial prefrontal cortex and dorsomedial striatum are necessary for odor span capacity in rats: role of GluN2B-containing NMDA receptors.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Switches in reward outcomes or reward-predictive cues are two fundamental ways in which information is used to flexibly shift response patterns. The rat prelimbic cortex and dorsomedial striatum support behavioral flexibility based on a change in outcomes. The present experiments investigated whether these two brain regions are necessary for conditional discrimination performance in which a switch in reward-predictive cues occurs every three to six trials. The GABA agonists baclofen and muscimol infused into the prelimbic cortex significantly impaired performance leading rats to adopt an inappropriate turn strategy. The NMDA receptor antagonist D-AP5 infused into the dorsomedial striatum or prelimbic cortex and dorsomedial striatum contralateral disconnection impaired performance due to a rat failing to switch a response choice for an entire trial block in about two out of 13 test blocks. In an additional study, contralateral disconnection did not affect nonswitch discrimination performance. The results suggest that the prelimbic cortex and dorsomedial striatum are necessary to support cue-guided behavioral switching. The prelimbic cortex may be critical for generating alternative response patterns while the dorsomedial striatum supports the selection of an appropriate response when cue information must be used to flexibly switch response patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.