Evidence map›Paper›PMID 25028166›Full record

ArticleHeart and vessels2015

A high-risk patient with long-QT syndrome with no response to cardioselective beta-blockers.

Naoki Toyota, Aya Miyazaki, Heima Sakaguchi, Wataru Shimizu, Hideo Ohuchi

Abstract readCase Reports
PubMed Publisher
In one paragraph

Article in Heart and vessels, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Naoki ToyotaDepartment of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan. n-toyota@otsu.jrc.or.jp.
Aya MiyazakiDepartment of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Heima SakaguchiDepartment of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Wataru ShimizuDepartment of Cardiovascular Medicine, Division of Arrhythmias and Electrophysiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
Hideo OhuchiDepartment of Pediatric Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan.
National Cerebral and Cardiovascular Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a case of a high-risk 19-year-old female with long-QT syndrome (LQTS) with compound mutations. She had a history of aborted cardiac arrest and syncope and had received treatment with propranolol for 15 years. However, because she developed adult-onset asthma we tried to switch propranolol, a nonselective beta-blocker, to beta-1-cardioselective agents, bisoprolol and metoprolol. These resulted in both a markedly prolonged corrected QT interval and the development of LQTS-associated arrhythmias. Eventually, propranolol was reinitiated at a higher dose with the addition of verapamil, and she has had no further cardiac or asthmatic events for 5 years.

Indexed as

Drug ToleranceElectrocardiographyAdrenergic beta-AntagonistsFemaleHumansLong QT SyndromeYoung AdultAdrenergic beta-AntagonistsBeta-1 selective blockerBeta-blockerHigh-risk patientLong-QT syndromeNonselective beta-blocker

Identifiers

PMID25028166
OpenAlexW2066769859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.