Evidence map›Paper›PMID 25028086›Full record

ArticleEuropean journal of clinical nutrition2014

Association of red blood cell n-3 polyunsaturated fatty acids with plasma inflammatory biomarkers among the Quebec Cree population.

M-È Labonté, E Dewailly, M Lucas, P Couture, B Lamarche

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in European journal of clinical nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03649828 (USE OF KEFIR AS A CO-ADJUVANT IN THE TREATMENT OF METABOLIC SYNDROME COMPONENTS), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03649828 nacompletednot on this mapstarted 2016, after this paper: background citation

USE OF KEFIR AS A CO-ADJUVANT IN THE TREATMENT OF METABOLIC SYNDROME COMPONENTS: a Double-blind, Randomized, Placebo Controlled Clinical Trial

TypeinterventionalSponsorUniversity Vila VelhaRan2016 to 2017Enrolled48ConditionsMetabolic Syndrome, Cardiovascular Diseases, HypertensionArmsprobiotic milk fermented with kefir grains, curd
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Article
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  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M-È LabontéInstitute of Nutrition and Functional Foods, Laval University, Québec, Quebec, Canada.
E Dewailly1] Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Québec, Quebec, Canada [2] Department of Social and Preventive Medicine, Laval University, Québec, Quebec, Canada.
M Lucas1] Axe Santé des Populations et Pratiques Optimales en Santé, Centre de Recherche du CHU de Québec, Québec, Quebec, Canada [2] Department of Social and Preventive Medicine, Laval University, Québec, Quebec, Canada.
P CoutureInstitute of Nutrition and Functional Foods, Laval University, Québec, Quebec, Canada.
B LamarcheInstitute of Nutrition and Functional Foods, Laval University, Québec, Quebec, Canada.
Université Laval · CA

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

BACKGROUND/

objectivesWe examined the prevalence of elevated plasma high-sensitivity C-reactive protein (hs-CRP) concentrations and associations with red blood cell (RBC) long-chain n-3 polyunsaturated fatty acids (LCn-3PUFA) in the James Bay Cree population from the province of Quebec (Canada). SUBJECTS/

methodsA total of 744 Cree adults (18-91 years) from seven communities of Eastern James Bay were included in these cross-sectional analyses. Associations between RBC LCn-3PUFA and proinflammatory markers (hs-CRP, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)) were assessed by using multivariate general linear models with adjustment for sex, age and waist circumference. An arbitrary inflammation score was defined based on the sum of the quartiles of hs-CRP, IL-6 and TNF-α concentrations (range=3-12).

resultsElevated hs-CRP concentrations (>3 mg/l) were present in 46.9% (95% confidence interval (CI) 43.3-50.5) of the James Bay Cree population. RBC docosapentaenoic acid (DPAn-3; C22:5n-3) was inversely associated with hs-CRP, TNF-α and the inflammation score (all P trend<0.02), whereas eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3) in RBC were not associated with inflammation (all P trend>0.18). Among participants with RBC DPAn-3 levels above the median of the population, odds ratio of having an elevated inflammation score (≥9) was 0.67 (95% CI, 0.48-0.93) compared with participants below the median.

conclusionsRESULTS indicate that low-grade systemic inflammation is highly prevalent and that higher RBC DPAn-3 levels are associated with a lower risk of systemic inflammation in the James Bay Cree population.

Indexed as

Indians, North AmericanAdultBiomarkersC-Reactive ProteinCross-Sectional StudiesDocosahexaenoic AcidsEicosapentaenoic AcidErythrocytesFatty Acids, Omega-3Fatty Acids, UnsaturatedFemaleHumansInflammationInterleukin-6MalePrevalenceBiomarkersC-Reactive ProteinDocosahexaenoic Acidsdocosapentaenoic acidEicosapentaenoic AcidFatty Acids, Omega-3Fatty Acids, UnsaturatedInterleukin-6Tumor Necrosis Factor-alpha

Identifiers

PMID25028086
OpenAlexW2029397153

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.