Evidence map›Paper›PMID 25028012›Full record

ArticleThe Journal of chemical physics2014

A new broadband homonuclear mixing pulse for NMR with low applied power.

Paul Coote, Kendra E Leigh, Tsyr-Yan Yu, Navin Khaneja, Gerhard Wagner, Haribabu Arthanari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of chemical physics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paul CooteSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02318, USA.
Kendra E LeighDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Tsyr-Yan YuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Navin KhanejaSchool of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02318, USA.
Gerhard WagnerDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Haribabu ArthanariDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Funding

T CELL SPECIFIC TRANSCRIPTION COMPLEXESP01GM047467 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAGNER, GERHARD · 1992 to 2017
$28.6M
OverallP41EB002026 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2003 to 2018
$17.9M
Structure and interactions of the Voltage-Dependent Anion Channel(VDAC)R01GM075879 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAGNER, GERHARD · 2005 to 2013
$2.3M
Novel targets to regulate NF-kB & SREBP activity: an approach to combat diabetesK01DK085198 · NIDDK · HARVARD MEDICAL SCHOOL · PI ARTHANARI, HARIBABU · 2010 to 2012
$455k
NIBIB NIH HHS P41 EB002026NIBIB NIH HHS P41-EB002026NIDDK NIH HHS K01 DK085198NIDDK NIH HHS K01-DK085198NIGMS NIH HHS GM047467NIGMS NIH HHS GM075879NIGMS NIH HHS P01 GM047467NIGMS NIH HHS R01 GM075879
6 · The paper itself

Abstract

Broadband homonuclear mixing pulses with low radiofrequency power are essential for NMR spectroscopy of proteins and small molecules, especially for emerging applications in high field NMR. We have analytically designed a mixing pulse with high bandwidth-to-power ratio, using our recently developed multi-frame method. Here, we compare the new pulse, NF4 (mixing in the fourth nutating frame), to the best currently available sequence, focusing on the low-power regime. We use simulations and experiments to compare the two pulses' relaxation properties and bandwidth, and demonstrate that NF4 has approximately 1.35 times higher bandwidth, with similar effective relaxation. Therefore, NF4 is a good choice for broadband homonuclear mixing, particularly when the available radiofrequency power is limited.

Indexed as

Magnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularSequence Analysis, ProteinCarbon IsotopesProteinsRadio WavesCarbon IsotopesProteins

Identifiers

PMID25028012
PMCPMC4104837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.