ArticleEuropean radiology2014
Left atrial dysfunction in type 2 diabetes mellitus: insights from cardiac MRI.
Article in European radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- The impact of lifestyle intervention on left atrial function in type 2 diabetes: results from the DIASTOLIC study.The international journal of cardiovascular imaging · 2022Trial
- Vitamin D Attenuates Left Atrial Volume Changes in African American Males with Obesity and Prediabetes.Echocardiography (Mount Kisco, N.Y.) · 2016Trial
- Comparing incidence of heart failure in individuals with enlarged cardiac chambers versus diabetes.American journal of preventive cardiology · 2026Article
- Demographic and cardiovascular risk factors associated with blood flow characteristics of the left atrium and left atrial appendage.European radiology · 2026Observational
- Left atrial filling index and stiffness index and its correlation to the duration of diabetes in patients with type II diabetes mellitus.The international journal of cardiovascular imaging · 2025Article
- Left-atrioventricular interaction and left-atrial deformation in patients with type 2 diabetes mellitus with or without chronic aortic regurgitation: a 3.0-T cardiac magnetic resonance feature-tracking study.Quantitative imaging in medicine and surgery · 2025Article
- Assessment of left atrial function and left atrioventricular coupling via cardiac magnetic resonance in individuals with prediabetes and diabetes.Acta diabetologica · 2025Article
- Diabetic cardiomyopathy: pathophysiology, imaging assessment and therapeutical strategies.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- Interaction effect of type 2 diabetes mellitus and hypertension on left atrial function: a three-dimensional echocardiography study.Quantitative imaging in medicine and surgery · 2023Article
- Three-Dimensional Automated, Machine-Learning-Based Left Heart Chamber Metrics: Associations with Prevalent Vascular Risk Factors and Cardiovascular Diseases.Journal of clinical medicine · 2022Article
- Left atrial structure and function are associated with cardiovascular outcomes independent of left ventricular measures: a UK Biobank CMR study.European heart journal. Cardiovascular Imaging · 2022Article
- Review
- Left Ventricular Diastolic Function Studied with Magnetic Resonance Imaging: A Systematic Review of Techniques and Relation to Established Measures of Diastolic Function.Diagnostics (Basel, Switzerland) · 2021Review
- Characterization, Pathogenesis, and Clinical Implications of Inflammation-Related Atrial Myopathy as an Important Cause of Atrial Fibrillation.Journal of the American Heart Association · 2020Review
- Male sex adversely affects the phenotypic expression of diabetic heart disease.Therapeutic advances in endocrinology and metabolism · 2020Article
- Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats.Journal of cellular and molecular medicine · 2020Article
- Left atrium passive ejection fraction is the most sensitive index of type 2 diabetes mellitus-related cardiac changes.The international journal of cardiovascular imaging · 2018Article
- Association of left atrial structure and function and incident cardiovascular disease in patients with diabetes mellitus: results from multi-ethnic study of atherosclerosis (MESA).European heart journal. Cardiovascular Imaging · 2017Article
- Vorticity is a marker of diastolic ventricular interdependency in pulmonary hypertension.Pulmonary circulation · 2016Article
- The influence of type 2 diabetes on left atrial remodeling.Clinical cardiology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe left atrium (LA) modulates left ventricular filling through reservoir, conduit and booster pump functions. Only limited data exist on LA involvement in type 2 diabetes mellitus (DM2). This study sought to assess LA function in asymptomatic DM2 with cardiac MRI. We hypothesized that cardiac MRI can detect LA dysfunction in asymptomatic DM2.
methodsForty-five patients with asymptomatic DM2 and 24 normoglycaemic controls were studied. MRI cine imaging was performed to measure LA maximal and minimal volumes. A flow-sensitive phase-contrast gradient-echo sequence was used for flow measurements perpendicular to the orifice of the mitral valve, to quantify active LA stroke volume. LA total, passive and active emptying volumes and fractions were calculated.
resultsLA reservoir function, namely LA total ejection fraction, was significantly greater in controls compared to patients with DM2 (62.2 ± 5.2 vs 57.0 ± 7.6 %, P = 0.004). LA passive ejection fraction was also greater in the controls (26.2 ± 9.5 vs 16.1 ± 11.0 %, P < 0.001). Regarding parameters of LA booster pump function, LA active ejection fraction was not significantly different between groups. DM2 was demonstrated to be an independent determinant of LA function.
conclusionsCardiac MRI enables the detection of LA dysfunction in asymptomatic DM2, characterized by a reduction in LA reservoir and conduit functions. KEY POINTS: • Evaluation of left atrial function is feasible with cardiac MRI • Type 2 diabetes mellitus is associated with left atrial dysfunction • Left atrial function modulates left ventricular filling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.