ArticleDrug safety2014
Undesirable effects related to oral antineoplastic drugs: comparison between patients' internet narratives and a national pharmacovigilance database.
Article in Drug safety, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Systematic review on the prevalence, frequency and comparative value of adverse events data in social media.British journal of clinical pharmacology · 2015Pooled it
- Comparison of Online Patient Reviews and National Pharmacovigilance Data for Tramadol-Related Adverse Events: Comparative Observational Study.JMIR public health and surveillance · 2022Observational
- Social Media Analytics for Pharmacovigilance of Antiepileptic Drugs.Computational and mathematical methods in medicine · 2022Article
- Complementing the US Food and Drug Administration Adverse Event Reporting System With Adverse Drug Reaction Reporting From Social Media: Comparative Analysis.JMIR public health and surveillance · 2020Article
- Combining Social Media and FDA Adverse Event Reporting System to Detect Adverse Drug Reactions.Drug safety · 2020Article
- Prospective Evaluation of Adverse Event Recognition Systems in Twitter: Results from the Web-RADR Project.Drug safety · 2020Article
- Methods to Compare Adverse Events in Twitter to FAERS, Drug Information Databases, and Systematic Reviews: Proof of Concept with Adalimumab.Drug safety · 2018Article
- Social media as a tool for assessing patient perspectives on quality of life in metastatic melanoma: a feasibility study.Health and quality of life outcomes · 2018Article
- Utility of social media and crowd-intelligence data for pharmacovigilance: a scoping review.BMC medical informatics and decision making · 2018Article
- Use of Social Media in the Assessment of Relative Effectiveness: Explorative Review With Examples From Oncology.JMIR cancer · 2018Article
- Mining Patients' Narratives in Social Media for Pharmacovigilance: Adverse Effects and Misuse of Methylphenidate.Frontiers in pharmacology · 2018Article
- Descriptions of Adverse Drug Reactions Are Less Informative in Forums Than in the French Pharmacovigilance Database but Provide More Unexpected Reactions.Frontiers in pharmacology · 2018Article
- Evaluation of Facebook and Twitter Monitoring to Detect Safety Signals for Medical Products: An Analysis of Recent FDA Safety Alerts.Drug safety · 2017Article
- Predicting Drug Recalls From Internet Search Engine Queries.IEEE journal of translational engineering in health and medicine · 2017Article
- Can social media data lead to earlier detection of drug-related adverse events?Pharmacoepidemiology and drug safety · 2016Article
- Social Media Listening for Routine Post-Marketing Safety Surveillance.Drug safety · 2016Article
- Pooled bioequivalence study database from Turkey: characterization of adverse events and determination of split points based on Gini Index as a promising method.SpringerPlus · 2016Article
- Patient Participation and the Use of Ehealth Tools for Pharmacoviligance.Frontiers in pharmacology · 2016Review
- Signal for Thrombosis with Eltrombopag and Romiplostim: A Disproportionality Analysis of Spontaneous Reports Within VigiBase®.Drug safety · 2015Article
- Adverse Drug Reaction Identification and Extraction in Social Media: A Scoping Review.Journal of medical Internet research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Internet is changing the way people learn about health and illness. Over the previous decade, the oral antineoplastic (OAN) agents have changed patient management allowing more ambulatory care. In this regard, websites could be an interesting source of data about OAN-induced adverse events (AEs).
objectiveThe aim of the study was to describe the characteristics of AEs, as reported on websites by patients exposed to OAN agents, and to compare these to those recorded in the French pharmacovigilance database (FPVD).
methodsWe performed a retrospective study to collect AEs reported by patients in five of the best-known website forums in France over 1 year (2011). For each report, we recorded demographic data, cancer type, drug involved and AEs. The same analysis was done in the FPVD for OAN-induced adverse drug reactions (ADRs).
resultsA total of 202 AEs were identified in website posts and 1,448 ADRs were found in the FPVD. The most cited drugs in websites were protein kinase inhibitors (n = 88, 43.5%) and hormone antagonists (n = 61, 30.2%). More musculoskeletal disorder reports were found in the patient websites compared with the FPVD (16.34 vs. 4.70%, p < 0.001). As for skin disorders, we collected fewer reports in the patient website forums than in the FPVD (13.37 vs. 22.17%, p = 0.004). AEs reported in the patient websites were less serious (n = 10, 4.95%) than ADRs recorded in the FPVD (n = 999, 68.99%) (p < 0.001).
conclusionsAEs reported in the website forums are considered by patients to be relevant enough to be shared. Data from patient websites could be used as a source of data to detect AEs alongside conventional pharmacovigilance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.