ArticleBiological research2014
Robertsonian chromosomes and the nuclear architecture of mouse meiotic prophase spermatocytes.
Article in Biological research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Centromere regulation in the germline and early embryo.Current opinion in genetics & development · 2025Review
- Crossover frequencies in spermatocytes of Robertsonian homozygotes and heterozygotes of Mus musculus domesticus.Genetics and molecular biology · 2025Article
- Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone.Scientific reports · 2022Article
- Quantitative analysis of Robertsonian chromosomes inherited by descendants from multiple Rb heterozygotes ofFrontiers in cell and developmental biology · 2022Article
- Article
- The impact of chromosomal fusions on 3D genome folding and recombination in the germ line.Nature communications · 2021Article
- Meiosis reveals the early steps in the evolution of a neo-XY sex chromosome pair in the African pygmy mouse Mus minutoides.PLoS genetics · 2020Article
- Meiotic Nuclear Architecture in Distinct Mole Vole Hybrids with Robertsonian Translocations: Chromosome Chains, Stretched Centromeres, and Distorted Recombination.International journal of molecular sciences · 2020Article
- BRUCE preserves genomic stability in the male germline of mice.Cell death and differentiation · 2020Article
- Comparative Chromosome Mapping of Musk Ox and the X Chromosome among Some Bovidae Species.Genes · 2019Article
- Chromosome Translocations as a Driver of Diversification in Mole VolesInternational journal of molecular sciences · 2019Article
- The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis.Chromosoma · 2019Article
- Meiotic behavior of a complex hexavalent in heterozygous mice for Robertsonian translocations: insights for synapsis dynamics.Chromosoma · 2019Article
- The effect of Robertsonian translocations on the intranuclear positioning of NORs (nucleolar organizing regions) in human sperm cells.Scientific reports · 2019Article
- Article
- Hexavalents in spermatocytes of Robertsonian heterozygotes between Mus m. domesticus 2n=26 from the Vulcano and Lipari Islands (Aeolian Archipelago, Italy).European journal of histochemistry : EJH · 2018Article
- Article
- Synaptic configuration of quadrivalents and their association with the XY bivalent in spermatocytes of Robertsonian heterozygotes of Mus domesticus.Biological research · 2017Article
- Cytological basis of sterility in male and female hybrids between sibling species of grey voles Microtus arvalis and M. levis.Scientific reports · 2016Article
- Meiotic behaviour of evolutionary sex-autosome translocations in Bovidae.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2016Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe nuclear architecture of meiotic prophase spermatocytes is based on higher-order patterns of spatial associations among chromosomal domains from different bivalents. The meiotic nuclear architecture depends on the chromosome characteristics and consequently is prone to modification by chromosomal rearrangements. In this work, we consider Mus domesticus spermatocytes with diploid chromosome number 2n = 40, all telocentric, and investigate a possible modification of the ancestral nuclear architecture due to the emergence of derived Rb chromosomes, which may be present in the homozygous or heterozygous condition.
resultsIn the 2n = 40 spermatocyte nuclei random associations mediated by pericentromeric heterochromatin among the 19 telocentric bivalents ocurr at the nuclear periphery. The observed frequency of associations among them, made distinguishable by specific probes and FISH, seems to be the same for pairs that may or may not form Rb chromosomes. In the homozygote Rb 2n = 24 spermatocytes, associations also mediated by pericentromeric heterochromatin occur mainly between the three telocentric or the eight metacentric bivalents themselves. In heterozygote Rb 2n = 32 spermatocytes all heterochromatin is localized at the nuclear periphery, yet associations are mainly observed among the three telocentric bivalents and between the asynaptic axes of the trivalents.
conclusionsThe Rb chromosomes pose sharp restrictions for interactions in the 2n = 24 and 2n = 32 spermatocytes, as compared to the ample possibilities for interactions between bivalents in the 2n = 40 spermatocytes. Undoubtedly the emergence of Rb chromosomes changes the ancestral nuclear architecture of 2n = 40 spermatocytes since they establish new types of interactions among chromosomal domains, particularly through centromeric and heterochromatic regions at the nuclear periphery among telocentric and at the nuclear center among Rb metacentric ones.
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