ArticleBiological research2014
Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice.
Article in Biological research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Formulation and characterization of BBR loaded niosomes using saponin as a nonionic biosurfactant investigating synergistic effects to enhance antibacterial activity.Scientific reports · 2025Article
- Protein undernutrition reduces the efficacy of praziquantel in a murine model of Schistosoma mansoni infection.PLoS neglected tropical diseases · 2022Article
- Pathological and immunological evaluation of different regimens of praziquantel treatment in a mouse model of Schistosoma mansoni infection.PLoS neglected tropical diseases · 2022Article
- Antibacterial activity of a berberine nanoformulation.Beilstein journal of nanotechnology · 2022Article
- Botanical candidates from Saudi Arabian flora as potential therapeutics forSaudi journal of biological sciences · 2021Review
- Evaluation of Berberine as an Adjunct to TB Treatment.Frontiers in immunology · 2021Article
- Hepatosplenic Protective Actions ofFrontiers in veterinary science · 2021Article
- Histopathological and biochemical studies on immunocompetent and immunocompromisedJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Phytochemical Screening and Antiprotozoal Effects of the MethanolicMolecules (Basel, Switzerland) · 2020Article
- Efficacy ofJournal of traditional and complementary medicine · 2019Article
- Neuroprotective effects of berberine on recognition memory impairment, oxidative stress, and damage to the purinergic system in rats submitted to intracerebroventricular injection of streptozotocin.Psychopharmacology · 2019Article
- Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice.BMC complementary and alternative medicine · 2019Article
- Berberine attenuate staphylococcal enterotoxin B-mediated acute liver injury via regulating HDAC expression.AMB Express · 2018Article
- Efficacy of Sida pilosa Retz aqueous extract against Schistosoma mansoni - induced granulomatous inflammation in the liver and the intestine of mice: histomorphometry and gastrointestinal motility evaluation.BMC complementary and alternative medicine · 2018Article
- Potential Prophylactic Effect of Berberine against Rat Colon Carcinoma Induce by 1,2-Dimethyl HydrazineAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Berberine improves the intestinal antioxidant status of laboratory mice,Saudi journal of biological sciences · 2017Article
- Ceratonia siliqua pod extract ameliorates Schistosoma mansoni-induced liver fibrosis and oxidative stress.BMC complementary and alternative medicine · 2016Article
- Evaluation of Anthelmintic Activity and Composition of Pumpkin (Cucurbita pepo L.) Seed Extracts-In Vitro and in Vivo Studies.International journal of molecular sciences · 2016Article
- Role of berberine in Alzheimer's disease.Neuropsychiatric disease and treatment · 2016Review
- Impact of gold nanoparticles on brain of mice infected with Schistosoma mansoni.Parasitology research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSchistosomiasis is caused by helminth parasites of the genus Schistosoma. Berberine chloride (BER), an isoquinoline alkaloid, has been used in vivo for its antiparasitic, antioxidant and hepatoprotective properties. In this study, the protective effect of BER and praziquantel has been compared for the extent of schistosomiasis-induced oxidative stress in hepatic tissue of mice.
resultsS. mansoni was able to induce inflammation and injury to the liver, evidenced (i) by an increase in inflammatory cellular infiltrations, dilated sinusoids and vacuolated hepatocytes, (ii) by decreased levels of alanine and aspartate aminotransferases and increased levels of alkaline phosphatase, γ-glutamyl transferase in the liver homogenate, (iii) by increased production of nitric oxide and thiobarbituric acid reactive substances, and (iv) by lowered glutathione levels and decreased activities of catalase and superoxide dismutase, respectively. All these infection-induced parameters were significantly altered during BER treatment. In particular, berberine counteracted the S. mansoni-induced loss of glutathione and the activities of catalase and superoxide dismutase.
conclusionBased on these results, it is concluded that berberine could ameliorate pre-existing liver damage and oxidative stress conditions due to schistosomiasis.
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