ArticleeLife2014
Insect endosymbiont proliferation is limited by lipid availability.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 111 citations in OpenAlex.
- Friends or foes: Unraveling the tsetse fly-Spiroplasma symbiosis.PLoS neglected tropical diseases · 2026Review
- Spiroplasma Are Protective Heritable Symbionts With Low Physiological Impact in the Drosophilid Fly Zaprionus kolodkinae.Environmental microbiology reports · 2026Article
- Linking genomic variation in Spiroplasma endosymbionts to male production and male-killing in the pea aphid.BMC genomics · 2026Article
- Sand fly endosymbionts in Kenya: Rickettsia and Wolbachia associations with Leishmania and detection of Rickettsia africae.Parasites & vectors · 2026Article
- Insect Lipidomics: Advances, Applications, and Physiological Insights.Advances in experimental medicine and biology · 2026Review
- Insect Lipid Metabolism in the Presence of Symbiotic and Pathogenic Viruses and Bacteria.Advances in experimental medicine and biology · 2026Review
- Lipid Metabolism as a Target Site in Pest Control.Advances in experimental medicine and biology · 2026Review
- Endosymbiont hijacking of acylcarnitines regulates insect vector fecundity by suppressing the viability of stored sperm.PLoS genetics · 2025Article
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- Comparative genomics and transcriptomics of theResearch square · 2025Article
- Diverse toxin repertoire but limited metabolic capacities inferred from the draft genome assemblies of threeMicrobial genomics · 2025Article
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- Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes.PLoS pathogens · 2025Article
- The Plasmodium transmission-blocking symbiont, Microsporidia MB, is vertically transmitted through Anopheles arabiensis germline stem cells.PLoS pathogens · 2024Article
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- The endosymbiontmBio · 2024Article
- Microorganism Contribution to Mass-Reared Edible Insects: Opportunities and Challenges.Insects · 2024Review
- Effect of Microsporidia MB infection on the development and fitness of Anopheles arabiensis under different diet regimes.Parasites & vectors · 2024Article
- Delayed host mortality and immune response upon infection withInfection and immunity · 2023Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Spiroplasma poulsonii is a maternally transmitted bacterial endosymbiont that is naturally associated with Drosophila melanogaster. S. poulsonii resides extracellularly in the hemolymph, where it must acquire metabolites to sustain proliferation. In this study, we find that Spiroplasma proliferation specifically depletes host hemolymph diacylglyceride, the major lipid class transported by the lipoprotein, Lpp. RNAi-mediated knockdown of Lpp expression, which reduces the amount of circulating lipids, inhibits Spiroplasma proliferation demonstrating that bacterial proliferation requires hemolymph-lipids. Altogether, our study shows that an insect endosymbiont acquires specific lipidic metabolites from the transport lipoproteins in the hemolymph of its host. In addition, we show that the proliferation of this endosymbiont is limited by the availability of hemolymph lipids. This feature could limit endosymbiont over-proliferation under conditions of host nutrient limitation as lipid availability is strongly influenced by the nutritional state.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.