ArticleBMC gastroenterology2014
The epidemiology and treatment of anal fissures in a population-based cohort.
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Efficacy and safety of topical vs. oral calcium channel blockers for chronic anal fissures: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- Comparing closed versus open lateral internal sphincterotomy for management of chronic anal fissure: systematic review and meta-analysis of randomised control trials.Scientific reports · 2023Pooled it
- Management options for chronic anal fissure: a systematic review of randomised controlled trials.International journal of colorectal disease · 2020Pooled it
- Pelvic floor physical therapy in the treatment of chronic anal fissure (PAF trial): quality of life outcome.Techniques in coloproctology · 2023Trial
- Five-year trends in proctological practice in Dubai: Insights from a high-volume referral centre.BMC surgery · 2026Article
- Global Management of Anal Fissure: Results from the ISUCRS 2022 Snapshot Audit.Journal of clinical medicine · 2026Article
- Efficacy of botulinum toxin type A administration within the current therapeutic algorithm for chronic anal fissure: study protocol for the prospective multicentre observational study FISURBOT-GECO6.Techniques in coloproctology · 2026Article
- Impact of sentinel pile on botulinum toxin treatment of chronic anal fissure: A comparative study.Techniques in coloproctology · 2026Observational
- Combined Tribenoside/Lidocaine Rectal Cream (Procto-GlyvenolPharmaceuticals (Basel, Switzerland) · 2026Article
- Benign anorectal conditions in a rural referral Sudanese hospital: a four-year retrospective review of patients' characteristics in a low-resource setting.BMC surgery · 2026Article
- Spectrum and Management of Anorectal Disorders: A Retrospective Analysis From the United Arab Emirates.Cureus · 2026Article
- Article
- Therapy and long-term outcomes of acute anal fissure: a high-volume referral centre experience with 623 patients.Techniques in coloproctology · 2026Article
- Management of chronic anal fissures: should fissurectomy be performed with botulinum toxin injection?Techniques in coloproctology · 2025Article
- Depression in patients with anorectal fistulas and anal fissures: a propensity score-matched cohort study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Revealing the Molecular Mechanism ofCombinatorial chemistry & high throughput screening · 2025Article
- Anal fissures in COVID-19 survivors: Incidence, risk factors, and outcomes.Turkish journal of surgery · 2024Article
- Description and management of patients with anal fissure: insights on Italian primary care setting coming from real-world data.Updates in surgery · 2024Article
- Is chemodenervation with incobotulinumtoxinA an alternative to invasive chronic anal fissure treatments?BMC gastroenterology · 2024Article
- Anal Fissure and Its Treatments: A Historical Review.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnal fissure (AF) is regarded as a common problem, but there are no published epidemiologic data, nor information on current treatment. The purpose of this study was to examine the incidence, associated comorbidities, and treatment of AF in a population-based cohort.
methodsWe conducted a retrospective analysis of all persons who were enrolled in one large regional managed care system and treated for AF during calendar years 2005-2011. All persons aged 6 years or older who had a clinic, hospitalization, or surgical procedure associated with AF were identified from utilization data. To identify comorbidities associated with AF, each case was matched by age and gender to 3 controls.
resultsThere were 1,243 AF cases, including 721 (58%) females and 522 (42%) males; 150 (12%) of the cases occurred in children aged 6-17 years. The overall annual incidence was 0.11% (1.1 cases per 1000 person-years), but ranged widely by age [0.05% in patients 6-17 years to 0.18% in patients 25-34 years]. The incidence also varied by sex, and was significantly higher among females 12-24 years, and among males 55-64 years (P < 0.001). Comorbidities associated with AF included chronic constipation (prevalence 14.2% vs 3.6%), hypothyroidism (14.7% vs 10.4%), obesity (13.0% vs 7.7%), and solid tumors without metastasis (5.2% vs 3.7%) (P < 0.001 for all comparisons). A total of 448 were dispensed a topical prescription medication, 31 had botulinum toxin injection, and only 13 had lateral internal sphincterotomy.
conclusionsAF is a common clinical problem, and the incidence varies substantially by age and sex. Constipation, obesity, and hypothyroidism are associated comorbidities. Most patients are prescribed topical treatments, although it appears that many prescriptions are never filled. Surgical interventions for AF including botulinum toxin and lateral internal sphincterotomy are uncommon.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.