ArticleThe Journal of pediatrics2014
Viral respiratory tract infections in the neonatal intensive care unit: the VIRIoN-I study.
Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed.
- Healthcare-associated parechovirus-A infection in hospitals with neonatal units in Japan: a nationwide survey.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Rapid diagnosis of acute pediatric respiratory infections with Point-of-Care and multiplex molecular testing.Infection · 2025Review
- Raising AWaRe-ness of Antimicrobial Stewardship Challenges in Pediatric Emergency Care: Results from the PERFORM Study Assessing Consistency and Appropriateness of Antibiotic Prescribing Across Europe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
- Surveillance of Viral Respiratory Infections in the Neonatal Intensive Care Unit-Evolution in the Last 5 Years.Pathogens (Basel, Switzerland) · 2023Article
- Tackling Neonatal Sepsis-Can It Be Predicted?International journal of environmental research and public health · 2023Article
- [Effect of improvement in antibiotic use strategy on the short-term clinical outcome of preterm infants with a gestational age of <35 weeks].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- In-hospital respiratory viral infections for patients with established BPD in the SARS-CoV-2 era.Pediatric pulmonology · 2022Article
- Neurodevelopmental outcomes following neonatal late-onset sepsis and blood culture-negative conditions.Archives of disease in childhood. Fetal and neonatal edition · 2021Article
- A novel anellovirus from hospitalized neonates.Archives of virology · 2021Article
- A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and resistance (NO-MAS-R) study.EClinicalMedicine · 2021Article
- The Problem of Microbial Dark Matter in Neonatal Sepsis.Emerging infectious diseases · 2020Article
- Low Frequency of Viral Respiratory Tract Infections During Family-Centered Neonatal Intensive Care: Results of a Prospective Surveillance Study.Frontiers in pediatrics · 2020Article
- Viral respiratory infections in very low birthweight infants at neonatal intensive care unit: prospective observational study.BMJ paediatrics open · 2020Article
- Hospital-acquired viral respiratory infections in neonates hospitalized since birth in a tertiary neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Respiratory viral infections in infants with possible sepsis.Journal of medical virology · 2019Article
- Impact of respiratory viruses in the neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Burden, Etiology, and Risk Factors of Respiratory Virus Infections Among Symptomatic Preterm Infants in the Tropics: A Retrospective Single-Center Cohort Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Article
- Validation of the Sepsis MetaScore for Diagnosis of Neonatal Sepsis.Journal of the Pediatric Infectious Diseases Society · 2018Article
- Viral Respiratory Infections in the Neonatal Intensive Care Unit-A Review.Frontiers in microbiology · 2018Review
- [Rhinovirus: Underestimated pathogens in patients during the neonatal period].Archives de pediatrie : organe officiel de la Societe francaise de pediatrie · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the frequency of respiratory viral infections among infants who were evaluated for late-onset sepsis in the neonatal intensive care units (NICUs) of Parkland Memorial Hospital, Dallas, Texas; and Women & Infants Hospital, Providence, Rhode Island. STUDY
designProspective cohort study conducted from January 15, 2012 to January 31, 2013. Infants in the NICU were enrolled if they were inborn, had never been discharged home, and were evaluated for sepsis (at >72 hours of age) and antibiotic therapy was initiated. Infants had a nasopharyngeal specimen collected for detection of respiratory viruses by multiplex polymerase chain reaction within 72 hours of the initiation of antibiotic therapy. Their medical records were reviewed for demographic, clinical, radiographic, and laboratory data until NICU discharge.
resultsDuring the 13-month study, 8 of 100 infants, or 8 (6%) of the 135 sepsis evaluations, had a respiratory virus detected by polymerase chain reaction (2, enterovirus/rhinovirus; 2, rhinovirus; 2, coronaviruses; and 2, parainfluenza-3 virus). By bivariate analysis, the infants with viral detection were older (41 vs 11 days; P = .007), exposed to individuals with respiratory tract viral symptoms (37% vs 2%; P = .003), tested for respiratory viruses by provider (75% vs 11%; P < .001), and had lower total neutrophil counts (P = .02). In multivariate regression analysis, the best predictor of viral infection was the caregivers' clinical suspicion of viral infection (P = .006).
conclusionsA total of 8% of infants, or 6% of all NICU sepsis evaluations, had a respiratory virus detected when evaluated for bacterial sepsis. These findings argue for more respiratory viral testing of infants with suspected sepsis using optimal molecular assays to establish accurate diagnoses, prevent transmission, and inform antibiotic stewardship efforts.
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