Evidence map›Paper›PMID 25027329›Full record

ArticleHuman molecular genetics2014

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

Zhaoming Wang, Bin Zhu, Mingfeng Zhang, Hemang Parikh, Jinping Jia, Charles C Chung, Joshua N Sampson, Jason W Hoskins, Amy Hutchinson, Laurie Burdette and 341 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 14 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 14 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
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  9. TERT rs10069690 polymorphism and cancers risk: A meta-analysis.Molecular genetics & genomic medicine · 2019
    Pooled it
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  15. Trial
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  19. Review
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21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

351 authors at 20 institutions in 26 countries.

Zhaoming WangDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Bin ZhuDivision of Cancer Epidemiology and Genetics.
Mingfeng ZhangDivision of Cancer Epidemiology and Genetics.
Hemang ParikhDivision of Cancer Epidemiology and Genetics.
Jinping JiaDivision of Cancer Epidemiology and Genetics.
Charles C ChungDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Joshua N SampsonDivision of Cancer Epidemiology and Genetics.
Jason W HoskinsDivision of Cancer Epidemiology and Genetics.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Laurie BurdetteDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Abdisamad IbrahimDivision of Cancer Epidemiology and Genetics.
Christopher HautmanDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Preethi S RajDivision of Cancer Epidemiology and Genetics.
Christian C AbnetDivision of Cancer Epidemiology and Genetics.
Andrew A AdjeiKorle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana.
Anders AhlbomUnit of Epidemiology, Institute of Environmental Medicine.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics.
Naomi E AllenClinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK.
Christine B AmbrosoneDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Melinda AldrichDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Pilar AmianoPublic Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain, CIBERESP, CIBER Epidemiologia y Salud Publica, Madrid, Spain.
Christopher AmosGeisel School of Medicine at Dartmouth, Hanover, NH, USA.
Ulrika AnderssonDepartment of Radiation Sciences, Oncology.
Gerald AndrioleDivision of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA.
Irene L AndrulisLitwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Cecilia AriciDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Italy.
Alan A ArslanDepartment of Obstetrics and Gynecology and Department of Population Health, New York University School of Medicine, New York, NY, USA, New York University Cancer Institute, New York, NY, USA.
Melissa A AustinDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Dalsu BarisDivision of Cancer Epidemiology and Genetics.
Donald A BarkauskasDepartment of Preventive Medicine, Biostatistics Division, Keck School of Medicine and.
Bryan A BassigDivision of Cancer Epidemiology and Genetics, Division of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics.
Christine D BergDivision of Cancer Prevention.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics.
Pier Alberto BertazziDepartment of Clinical Sciences and Community Health, University of Milan, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Policlinico Hospital, Milan, Italy.
Richard B BiritwumKorle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana.
Amanda BlackDivision of Cancer Epidemiology and Genetics.
William BlotDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, International Epidemiology Institute, Rockville, MD, USA.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany.
Paolo BoffettaInstitute for Translational Epidemiology, Hematology and Medical Oncology, Mount Sinai Hospital School of Medicine, New York, NY, USA.
Kelly BoltonDivision of Cancer Epidemiology and Genetics, Department of Oncology, University of Cambridge, Cambridge CB2 2RE, UK.
Marie-Christine Boutron-RuaultInstitut National de la Sante et de la Recherche Medicale (INSERM) and Institut Gustave Roussy, Villejuif, France.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Paul BrennanInternational Agency for Research on Cancer (IARC-WHO), Lyon, France.
Louise A BrintonDivision of Cancer Epidemiology and Genetics.
Michelle BrotzmanWestat, Rockville, MD, USA.
H Bas Bueno-de-MesquitaNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Julie E BuringDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Mary Ann ButlerCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Geraldine Cancel-TassinCeRePP, Paris, France, UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Guangwen CaoDepartment of Epidemiology, Second Military Medical University, Shanghai, China.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics.
Alfredo CarratoMedical Oncology Department, Hospital Ramón y Cajal, Madrid, Spain.
Tania CarreonCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
Angela CartaLitwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Gee-Chen ChangFaculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
I-Shou ChangNational Institute of Cancer Research.
Jenny Chang-ClaudeGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Xu CheDepartment of Abdominal Surgery and.
Chien-Jen ChenGenomics Research Center, Academia Sinica, Taipei, Taiwan, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan.
Chih-Yi ChenCancer Center, China Medical University Hospital, Taipei, Taiwan.
Chung-Hsing ChenNational Institute of Cancer Research.
Constance ChenProgram in Molecular and Genetic Epidemiology.
Kuan-Yu ChenDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Yuh-Min ChenDepartment of Epidemiology and Public Health, Yong Loo Lin School of Medicine and Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, College of Medical Science and Technology, Taipei Medical University, Taiwan.
Anand P ChokkalingamSchool of Public Health, University of California, Berkeley, CA, USA.
Lisa W ChuCancer Prevention Institute of California, Fremont, CA, USA.
Francoise Clavel-ChapelonInserm, Centre for Research in Epidemiology and Population Health (CESP), Villejuif, France.
Graham A ColditzWashington University School of Medicine, St Louis, MO, USA.
Joanne S ColtDivision of Cancer Epidemiology and Genetics.
David ContiDepartment of Preventive Medicine, Biostatistics Division, Keck School of Medicine and.
Michael B CookDivision of Cancer Epidemiology and Genetics.
Victoria K CortessisDepartment of Preventive Medicine, Biostatistics Division, Keck School of Medicine and.
E David CrawfordUrologic Oncology, University of Colorado, Aurora, CO, USA.
Olivier CussenotCeRePP, Paris, France, AP-HP, Department of Urology, Tenon Hospital, GHU-Est, Paris, France, UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France.
Faith G DavisDepartment of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB, Canada T6G 2R3.
Immaculata De VivoProgram in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Xiang DengDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Ti DingShanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China.
Colin P DinneyDepartment of Urology.
Anna Luisa Di StefanoService de Neurologie Mazarin, GH Pitie-Salpetriere, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Eric J DuellUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Joanne W ElenaEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, Bethesda, MD, USA.
Jin-Hu FanShanghai Cancer Institute, Shanghai, People's Republic of China.
Heather Spencer FeigelsonInstitute for Health Research, Kaiser Permanente, Denver, CO, USA.
Maria FeychtingUnit of Epidemiology, Institute of Environmental Medicine.
Jonine D FigueroaDivision of Cancer Epidemiology and Genetics.
Adrienne M FlanaganUCL Cancer Institute, Huntley Street, London WC1E 6BT, UK, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics.
Neal D FreedmanDivision of Cancer Epidemiology and Genetics.
Brooke L FridleyDepartment of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.
Charles S FuchsDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Channing Laboratory, Department of Medicine.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.
Steven GallingerSamuel Lunenfeld Research Institute and.
Yu-Tang GaoDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of Medicine, Shanghai, China.
Susan M GapsturEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Montserrat Garcia-ClosasDivision of Cancer Epidemiology and Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK.
Reina Garcia-ClosasUnidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain.
Julie M Gastier-FosterNationwide Children's Hospital, and The Ohio State University Department of Pathology and Pediatrics, Columbus, OH, USA.
J Michael GazianoDivision of Preventive Medicine, Department of Medicine and Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA.
Daniela S GerhardOffice of Cancer Genomics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Carol A GiffenInformation Management Services Inc., Calverton, MD, USA.
Graham G GilesCancer Epidemiology Centre, The Cancer Council Victoria & Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Victoria, Australia.
Elizabeth M GillandersDivision of Cancer Control and Population Sciences and.
Edward L GiovannucciProgram in Molecular and Genetic Epidemiology, Department of Nutrition and.
Michael GogginsDepartment of Oncology, Department of Pathology and Department of Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nalan GokgozLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
Alisa M GoldsteinDivision of Cancer Epidemiology and Genetics.
Carlos GonzalezUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.
Richard GorlickAlbert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, NY, USA.
Mark H GreeneDivision of Cancer Epidemiology and Genetics.
Myron GrossDepartment of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA.
H Barton GrossmanDepartment of Urology.
Robert GrubbDepartment of Urology, Washington University School of Medicine, St Louis, MO, USA.
Jian GuDepartment of Epidemiology.
Peng GuanDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Goran HallmansDepartment of Public Health and Clinical Medicine/Nutritional Research.
Susan E HankinsonChanning Laboratory, Department of Medicine.
Curtis C HarrisLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Patricia HartgeDivision of Cancer Epidemiology and Genetics.
Claudia HattingerLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Richard B HayesDivision of Cancer Epidemiology and Genetics, Department of Population Health, New York University Langone Medical Center and Department of Environmental Medicine, New York University Langone Medical Center, New York University Cancer Institute, New York, NY, USA.
Qincheng HeDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Lee HelmanCenter for Cancer Research and.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Roger HenrikssonDepartment of Radiation Sciences, Oncology.
Judith Hoffman-BoltonJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Chancellor HohenseeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
Yun-Chul HongInstitute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea, Department of Preventive Medicine and.
Robert N HooverDivision of Cancer Epidemiology and Genetics.
H Dean HosgoodDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Chin-Fu HsiaoDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences and Taiwan Lung Cancer Tissue/Specimen Information Resource Center, National Health Research Institutes, Zhunan, Taiwan.
Ann W HsingCancer Prevention Institute of California, Fremont, CA, USA, Stanford Cancer Institute, Stanford University, Stanford, CA, USA.
Chao Agnes HsiungDivision of Biostatistics and Bioinformatics, Institute of Population Health Sciences and.
Nan HuDivision of Cancer Epidemiology and Genetics.
Wei HuDivision of Cancer Epidemiology and Genetics.
Zhibin HuDepartment of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Ming-Shyan HuangDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
David J HunterProgram in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Peter D InskipDivision of Cancer Epidemiology and Genetics.
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Eric J JacobsEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Kevin B JacobsCancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Bioinformed, LLC, Gaithersburg, MD, USA.
Mazda JenabInternational Agency for Research on Cancer (IARC-WHO), Lyon, France.
Bu-Tian JiDivision of Cancer Epidemiology and Genetics.
Christoffer JohansenDepartment of Oncology, Finsen Center, Rigshospitalet, Copenhagen, Denmark, Unit of Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark.
Mattias JohanssonInternational Agency for Research on Cancer (IARC-WHO), Lyon, France, Department of Public Health and Clinical Medicine.
Alison JohnsonVermont Cancer Registry, Burlington, VT, USA.
Rudolf KaaksGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ashish M KamatDepartment of Urology.
Aruna KamineniGroup Health Research Institute, Seattle, WA, USA.
Margaret KaragasGeisel School of Medicine at Dartmouth, Hanover, NH, USA.
Chand KhannaCenter for Cancer Research and.
Kay-Tee KhawSchool of Clinical Medicine, University of Cambridge, UK.
Christopher KimDivision of Cancer Epidemiology and Genetics.
In-Sam KimDepartment of Biochemistry and Department of Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Jin Hee KimInstitute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea.
Yeul Hong KimGenomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain and Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Young-Chul KimLung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea.
Young Tae KimCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Chang Hyun KangCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Yoo Jin JungCancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea.
Cari M KitaharaDivision of Cancer Epidemiology and Genetics.
Alison P KleinDepartment of Oncology, Department of Pathology and Department of Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Robert KleinDepartment of Medicine and.
Manolis KogevinasCentre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, National School of Public Health, Athens, Greece.
Woon-Puay KohDuke-NUS Graduate Medical School, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
Takashi KohnoDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Christian P KratzDivision of Cancer Epidemiology and Genetics.
Vittorio KroghFondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Hideo KunitohDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan, Department of Respiratory Medicine, Mitsui Memorial Hospital, Tokyo, Japan.
Robert C KurtzDepartment of Medicine and.
Nilgun KurucuDepartment of Pediatric Oncology, A.Y. Ankara Oncology Training and Research Hospital, Yenimahalle- Ankara, Turkey.
Qing LanDivision of Cancer Epidemiology and Genetics.
Mark LathropCentre National de Genotypage, IG/CEA, Evry Cedex, France, Centre d'Étude du Polymorphism Humain (CEPH), Paris, France.
Ching C LauTexas Children's Cancer and Hematology Centers.
Fernando LecandaDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain.
Kyoung-Mu LeeDepartment of Preventive Medicine and Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea.
Maxwell P LeeCenter for Cancer Research and.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
Seth P LernerScott Department of Urology and.
Donghui LiDepartment of Gastrointestinal Medical Oncology.
Linda M LiaoDivision of Cancer Epidemiology and Genetics.
Wei-Yen LimSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Dongxin LinState Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jie LinDepartment of Epidemiology.
Sara LindstromProgram in Molecular and Genetic Epidemiology.
Martha S LinetDivision of Cancer Epidemiology and Genetics.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland.
Jianjun LiuHuman Genetics Division, Genome Institute of Singapore, Singapore, School of Life Sciences, Anhui Medical University, Hefei, China.
Börje LjungbergDepartment of Surgical and Perioperative Sciences, Urology and Andrology and.
Josep LloretaCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Daru LuMinistry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China.
Jing MaDepartment of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Nuria MalatsCentro Nacional de Investigaciones Oncologicas, Melchor Fernández Almagro, 3, Madrid E-28029, Spain.
Satu MannistoNational Institute for Health and Welfare, Helsinki, Finland.
Neyssa MarinaLucile Packard Children's Hospital, Stanford University, Palo Alto, CA, USA.
Giuseppe MastrangeloDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy.
Keitaro MatsuoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan, Department of Preventive Medicine, Kyushu University Faculty of Medical Scicence, Fukuoka, Japan.
Katherine A McGlynnDivision of Cancer Epidemiology and Genetics.
Roberta McKean-CowdinDepartment of Epidemiology.
Lorna H McNeillDepartment of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community-Engaged Translational Research, Duncan Family Institute and.
Robert R McWilliamsDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Beatrice S MelinDepartment of Radiation Sciences, Oncology.
Paul S MeltzerCenter for Cancer Research and.
James E MensahKorle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana.
Xiaoping MiaoKey Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.
Dominique S MichaudDepartment of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA.
Alison M MondulDivision of Cancer Epidemiology and Genetics.
Lee E MooreDivision of Cancer Epidemiology and Genetics.
Kenneth MuirHealth Sciences Research Institute, University of Warwick, Coventry, UK.
Shelley NiwaWestat, Rockville, MD, USA.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Nick OrrComplex Traits Genetics Team and.
Salvatore PanicoDipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.
Jae Yong ParkDepartment of Biochemistry and Department of Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Lung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea.
Alpa V PatelEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Ana Patino-GarciaDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain.
Sofia PavanelloDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy.
Petra H M PeetersJulius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Utrecht, The Netherlands, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Beata PeplonskaNofer Institute of Occupational Medicine, Lodz, Poland.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic, Rochester, MN, USA.
Piero PicciLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Malcolm C PikeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Stefano PorruDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Italy.
Jennifer PrescottProgram in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Xia PuDepartment of Epidemiology.
Mark P PurdueDivision of Cancer Epidemiology and Genetics.
You-Lin QiaoDepartment of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Preetha RajaramanDivision of Cancer Epidemiology and Genetics.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Harvey A RischYale School of Public Health, New Haven, CT, USA.
Rebecca J RodaboughDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics.
Avima M RuderCenters for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA.
Jeong-Seon RyuDepartment of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
Marc SansonService de Neurologie Mazarin, GH Pitie-Salpetriere, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France.
Alan SchnedGeisel School of Medicine at Dartmouth, Hanover, NH, USA.
Fredrick R SchumacherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ann G SchwartzKarmanos Cancer Institute and Department of Oncology and.
Kendra L SchwartzKarmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA.
Molly SchwennMaine Cancer Registry, Augusta, ME, USA.
Katia ScotlandiLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Adeline SeowSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Consol SerraCentre for Research in Occupational Health, Universitat Pompeu Fabra, Barcelona, Spain, CIBER of Epidemiology and Public Health (CIBERESP).
Massimo SerraLaboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy.
Howard D SessoDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Gianluca SeveriCancer Epidemiology Centre, The Cancer Council Victoria & Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Victoria, Australia.
Hongbing ShenDepartment of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China.
Min ShenDivision of Cancer Epidemiology and Genetics.
Sanjay SheteDepartment of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Afshan SiddiqDepartment of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK.
Luis SierrasesumagaDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain.
Sabina SierriNutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Alan Dart Loon SihoeDepartment of Surgery, Division of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong, China.
Debra T SilvermanDivision of Cancer Epidemiology and Genetics.
Matthias SimonDepartment of Neurosurgery, University of Bonn Medical Center, Bonn, Germany.
Melissa C SoutheyDepartment of Pathology, The University of Melbourne, Melbourne, VIC, Australia.
Logan SpectorUniversity of Minnesota, Minneapolis, MN, USA.
Margaret SpitzDan L. Duncan Center, Baylor College of Medicine, Houston, TX, USA.
Meir StampferDepartment of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Par StattinDepartment of Surgical and Perioperative Sciences, Urology and Andrology and.
Mariana C SternDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Victoria L StevensEpidemiology Research Program, American Cancer Society, Atlanta, GA, USA.
Rachael Z Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sara S StromDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wu-Chou SuDepartment of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan.
Malin SundDepartment of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden.
Sook Whan SungDepartment of Thoracic and Cardiovascular Surgery, Seoul St Mary's Hospital, Seoul, South Korea.
Anthony SwerdlowDivision of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK, Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Wen TanState Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hideo TanakaDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan.
Wei TangDivision of Cancer Epidemiology and Genetics.
Ze-Zhang TangShanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China.
Adonina TardonInstituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain.
Evelyn TayKorle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana.
Philip R TaylorDivision of Cancer Epidemiology and Genetics.
Yao TetteyKorle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana.
David M ThomasSir Peter MacCallum Department of Oncology, University of Melbourne, St Andrew's Place, East Melbourne, VIC, Australia.
Roberto TiraboscoRoyal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK.
Anne TjonnelandDanish Cancer Society Research Center, Copenhagen, Denmark.
Geoffrey S TobiasDivision of Cancer Epidemiology and Genetics.
Jorge R ToroDivision of Cancer Epidemiology and Genetics.
Ruth C TravisClinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK.
Dimitrios TrichopoulosDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Rebecca TroisiDivision of Cancer Epidemiology and Genetics.
Ann TrueloveWestat, Rockville, MD, USA.
Ying-Huang TsaiDepartment of Pulmonary Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Margaret A TuckerDivision of Cancer Epidemiology and Genetics.
Rosario TuminoCancer Registry Associazione Iblea Ricerca Epidemiologica, Onlus and Asp Ragusa, Ragusa Italy.
David Van Den BergDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Stephen K Van Den EedenKaiser Permanente Northern California, Oakland, CA, USA.
Roel VermeulenDivision of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands.
Paolo VineisImperial College, London, UK, Human Genetics Foundation (HuGeF), Torino Italy.
Kala VisvanathanJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ulla VogelNational Research Centre for the Working Environment, Copenhagen, Denmark, National Food Institute, Technical University of Denmark, Soborg, Denmark.
Chaoyu WangDivision of Cancer Epidemiology and Genetics.
Chengfeng WangDepartment of Abdominal Surgery and.
Junwen WangDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
Sophia S WangDivision of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA.
Elisabete WeiderpassDepartment of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway, Department of Research, Cancer Registry of Norway, Oslo, Norway, Department of Medical Epidemiology and Biostatistics and Samfundet Folkhälsan, Helsinki, Finland.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics.
William WheelerInformation Management Services Inc., Calverton, MD, USA.
Emily WhiteDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
John K WienckeUniversity of California San Francisco, San Francisco, CA, USA.
Alicja WolkUnit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Channing Laboratory, Department of Medicine.
Maria Pik WongDepartment of Pathology and.
Margaret WrenschUniversity of California San Francisco, San Francisco, CA, USA.
Chen WuState Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Tangchun WuDepartment of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy.
Xifeng WuDepartment of Epidemiology.
Yi-Long WuGuangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Jay S WunderDivision of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA.
Yong-Bing XiangDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of Medicine, Shanghai, China.
Jun XuSchool of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Hannah P YangDivision of Cancer Epidemiology and Genetics.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Yasushi YatabeDepartment of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital and.
Yuanqing YeDepartment of Epidemiology.
Edward D YeboahKorle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana.
Zhihua YinDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Chen YingSaw Swee Hock School of Public Health, National University of Singapore, Singapore.
Chong-Jen YuDepartment of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan.
Kai YuDivision of Cancer Epidemiology and Genetics.
Jian-Min YuanUniversity of Pittsburgh Cancer Institute, Pittsburgh, PA, USA and.
Krista A ZanettiEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, Bethesda, MD, USA.
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, NY, USA, New York University Cancer Institute, New York, NY, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Baosen ZhouDepartment of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Lisa MirabelloDivision of Cancer Epidemiology and Genetics.
Sharon A SavageDivision of Cancer Epidemiology and Genetics.
Peter KraftProgram in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Meredith YeagerDivision of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Maria Terese LandiDivision of Cancer Epidemiology and Genetics.
Jianxin ShiDivision of Cancer Epidemiology and Genetics.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics.
Laufey T AmundadottirDivision of Cancer Epidemiology and Genetics, amundadottirl@mail.nih.gov.
Cancer Genetics (United States) · USFrederick National Laboratory for Cancer Research · USBrigham and Women's Hospital · USSeoul National University · KRUniversity of Southern California · USUniversity of Ghana · GHAmerican Cancer Society · USFred Hutch Cancer Center · USVanderbilt University · USCenter for Cancer Research · USChina Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNInserm · FRIstituto Ortopedico Rizzoli · ITJohns Hopkins University · USNational University of Singapore · SGThe University of Melbourne · AUUniversity of California, San Francisco · USWashington University in St. Louis · USAichi Cancer Center · JP

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Laboratory of Translational GenomicsZIACP010201 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PROKUNINA-OLSSON, LIUDMILA · 2010 to 2025
$91.2M
Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6M
Targeting Ral GTPases in Bladder CancerP50CA091846 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DINNEY, COLIN P.N., MCCONKEY, DAVID J. · 2001 to 2018
$37.4M
Tissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M. · 2004 to 2018
$32.7M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
Cancer Genomics Technology DevelopmentZIABC011091 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MELTZER, PAUL S. · 2009 to 2025
$16.9M
Cancer Research UK 14136Cancer Research UK 16491CCR NIH HHS HHSN261200800001CMedical Research Council G0401527Medical Research Council G1000143NCI NIH HHS HHSN261200800001ENCI NIH HHS K07 CA172294NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA015704NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA091846NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA057494NCI NIH HHS R01 CA092447NCI NIH HHS R01 CA154823NCI NIH HHS U10 CA180899NCI NIH HHS UM1 CA173640NCI NIH HHS UM1 CA182876NCI NIH HHS UM1 CA182910World Health Organization 001
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci.

Indexed as

Gene Expression Regulation, NeoplasticGenetic LociAllelesChromosomes, Human, Pair 5Computational BiologyDNA MethylationEpigenesis, GeneticFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMembrane ProteinsNeoplasm ProteinsNeoplasmsCLPTM1L protein, humanMembrane ProteinsNeoplasm ProteinsTelomeraseTERT protein, human

Identifiers

PMID25027329
PMCPMC4240198
OpenAlexW2170044093

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