ArticleJournal of materials science. Materials in medicine2014
Sequential assembly of 3D perfusable microfluidic hydrogels.
Article in Journal of materials science. Materials in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- A review of organ-on-chip fabrication methods: From early developments to overcoming inert barriers.iScience · 2025Review
- Review
- Advances in Hydrogel-Based Microfluidic Blood-Brain-Barrier Models in Oncology Research.Pharmaceutics · 2022Review
- Hydrogels as artificial matrices for cell seeding in microfluidic devices.RSC advances · 2020Review
- Modular Strategies to Build Cell-Free and Cell-Laden Scaffolds towards Bioengineered Tissues and Organs.Journal of clinical medicine · 2019Review
- Accurate flow in augmented networks (AFAN): an approach to generating three-dimensional biomimetic microfluidic networks with controlled flow.Analytical methods : advancing methods and applications · 2019Article
- Review: Mechanotransduction in ovarian cancer: Shearing into the unknown.APL bioengineering · 2018Review
- Image-guided, Laser-based Fabrication of Vascular-derived Microfluidic Networks.Journal of visualized experiments : JoVE · 2017Article
- Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations.Materials (Basel, Switzerland) · 2016Review
- A novel method for fabricating engineered structures with branched micro-channel using hollow hydrogel fibers.Biomicrofluidics · 2016Article
- Bio-printing cell-laden Matrigel-agarose constructs.Journal of biomaterials applications · 2016Article
- Fabrication of 3D Biomimetic Microfluidic Networks in Hydrogels.Advanced healthcare materials · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bottom-up tissue engineering provides a promising way to recreate complex structural organizations of native organs in artificial constructs by assembling functional repeating modules. However, it is challenging for current bottom-up strategies to simultaneously produce a controllable and immediately perfusable microfluidic network in modularly assembled 3D constructs. Here we presented a bottom-up strategy to produce perfusable microchannels in 3D hydrogels by sequentially assembling microfluidic modules. The effects of agarose-collagen composition on microchannel replication and 3D assembly of hydrogel modules were investigated. The unique property of predefined microchannels in transporting fluids within 3D assemblies was evaluated. Endothelial cells were incorporated into the microfluidic network of 3D hydrogels for dynamic culture in a house-made bioreactor system. The results indicated that the sequential assembly method could produce interconnected 3D predefined microfluidic networks in optimized agarose-collagen hydrogels, which were fully perfusable and successfully functioned as fluid pathways to facilitate the spreading of endothelial cells. We envision that the presented method could be potentially used to engineer 3D vascularized parenchymal constructs by encapsulating primary cells in bulk hydrogels and incorporating endothelial cells in predefined microchannels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.