ArticleStem cells and development2014
Adult stem cells from the hyaluronic acid-rich node and duct system differentiate into neuronal cells and repair brain injury.
Article in Stem cells and development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway.Genes & genomics · 2025Article
- Review
- In Vitro Simulated Neuronal Environmental Conditions Qualify Umbilical Cord Derived Highly Potent Stem Cells for Neuronal Differentiation.Stem cell reviews and reports · 2023Article
- The involvement of the primo vascular system in local enteritis and its modification by electroacupuncture.Frontiers in immunology · 2022Article
- Article
- Article
- Various stem cells in acupuncture meridians and points and their putative roles.Journal of traditional and complementary medicine · 2018Review
- VSELs Maintain their Pluripotency and Competence to Differentiate after Enhanced Ex Vivo Expansion.Stem cell reviews and reports · 2018Article
- Mouse Bone Marrow VSELs Exhibit Differentiation into Three Embryonic Germ Lineages and Germ & Hematopoietic Cells in Culture.Stem cell reviews and reports · 2017Article
- Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells.Stem cell research & therapy · 2016Article
- Monitoring the primo vascular system in lymphatic vessels by using window chambers.Biomedical optics express · 2016Article
- Ultrastructure of a Mobile Threadlike Tissue Floating in a Lymph Vessel.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Molecular and phenotypic characterization of CD133 and SSEA4 enriched very small embryonic-like stem cells in human cord blood.Leukemia · 2015Article
- Hypothesis on the Treatment of Gliomas with Acupuncture at the Primo Node Corresponding toMedical acupuncture · 2015Article
- Essential Experimental Methods for Identifying Bonghan Systems as a Basis for Korean Medicine: Focusing on Visual Materials from Original Papers and Modern Outcomes.Evidence-based complementary and alternative medicine : eCAM · 2015Review
- Primo-Vascular System as Presented by Bong Han Kim.Evidence-based complementary and alternative medicine : eCAM · 2015Review
Corrections and comments
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Authors and funding
7 authors.
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Abstract
The existence of a hyaluronic acid-rich node and duct system (HAR-NDS) within the lymphatic and blood vessels was demonstrated previously. The HAR-NDS was enriched with small (3.0-5.0 μm in diameter), adult stem cells with properties similar to those of the very small embryonic-like stem cells (VSELs). Sca-1(+)Lin(-)CD45(-) cells were enriched approximately 100-fold in the intravascular HAR-NDS compared with the bone marrow. We named these adult stem cells "node and duct stem cells (NDSCs)." NDSCs formed colonies on C2C12 feeder layers, were positive for fetal alkaline phosphatase, and could be subcultured on the feeder layers. NDSCs were Oct4(+)Nanog(+)SSEA-1(+)Sox2(+), while VSELs were Oct4(+)Nanog(+)SSEA-1(+)Sox2(-). NDSCs had higher sphere-forming efficiency and proliferative potential than VSELs, and they were found to differentiate into neuronal cells in vitro. Injection of NDSCs into mice partially repaired ischemic brain damage. Thus, we report the discovery of potential adult stem cells that may be involved in tissue regeneration. The intravascular HAR-NDS may serve as a route that delivers these stem cells to their target tissues.
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