ArticleEuropean journal of applied physiology2014
Bone formation is suppressed with multi-stressor military training.
Article in European journal of applied physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04939636 (The Influence of Vitamin D on the Physical Performance and General Health of Conscripts of the Estonian Defence Forces), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Influence of Vitamin D on the Physical Performance and General Health of Conscripts of the Estonian Defence Forces
Who cites it
20 citing papers in PubMed.
- Seven-month wintertime supplementation of 1200 IU vitamin D has no effect on hand grip strength in young, physically active males: A randomized, controlled study.Journal of the International Society of Sports Nutrition · 2022Trial
- Bone Turnover Markers After Sleep Restriction and Circadian Disruption: A Mechanism for Sleep-Related Bone Loss in Humans.The Journal of clinical endocrinology and metabolism · 2017Trial
- Weight Loss Before Basic Combat Training and Musculoskeletal Injuries Among U.S. Army Trainees: The ARMI Study.Obesity (Silver Spring, Md.) · 2025Article
- Synergistic Effects of an Eight-Week Resistance Training and Probiotic Supplementation on Bone Metabolism in Ovariectomized Rats.Preventive nutrition and food science · 2025Article
- Beyond physical exhaustion: Understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation.Sports medicine and health science · 2025Review
- Association between sleep duration and hip fracture risk among the older adults: a cross-sectional study based on the NHANES.BMC musculoskeletal disorders · 2025Article
- Predictive Validity of Multifactorial Injury Risk Models and Associated Clinical Measures in the U.S. Population.Sports (Basel, Switzerland) · 2024Article
- Sex differences in energy balance, body composition, and metabolic and endocrine markers during prolonged arduous military training.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Intracortical remodelling increases in highly loaded bone after exercise cessation.Journal of anatomy · 2024Article
- The effect of sex and protein supplementation on bone metabolism during a 36-h military field exercise in energy deficit.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Utility of HR-pQCT in detecting training-induced changes in healthy adult bone morphology and microstructure.Frontiers in physiology · 2023Review
- Bone Turnover Markers After Six Nights of Insufficient Sleep and Subsequent Recovery Sleep in Healthy Men.Calcified tissue international · 2022Article
- Sleep Disruption and Bone Health.Current osteoporosis reports · 2022Review
- Biomechanical Basis of Predicting and Preventing Lower Limb Stress Fractures During Arduous Training.Current osteoporosis reports · 2021Review
- Sleep duration and bone health measures in older men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Sleep Restriction With Circadian Disruption Negatively Alter Bone Turnover Markers in Women.The Journal of clinical endocrinology and metabolism · 2020Article
- Energy Deficiency in Soldiers: The Risk of the Athlete Triad and Relative Energy Deficiency in Sport Syndromes in the Military.Frontiers in nutrition · 2020Review
- Bone turnover is altered during 72 h of sleep restriction: a controlled laboratory study.Endocrine · 2019Article
- The role of adaptive bone formation in the etiology of stress fracture.Experimental biology and medicine (Maywood, N.J.) · 2017Review
- Obstructive sleep apnea and metabolic bone disease: insights into the relationship between bone and sleep.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the effects of US Army Ranger Training, an 8-week, physically demanding program (energy expenditure of 2,500-4,500 kcal/day) with energy restriction (deficit of 1,000-4,000 kcal/day) and sleep deprivation (<4 h sleep/night) on bone metabolism.
methodsBlood was collected from 22 men (age 24 ± 4 years) before and after training. Follow-up measurements were made in a subset of 8 subjects between 2 and 6 weeks after training. Serum was analyzed for bone formation biomarkers [bone alkaline phosphatase (BAP) and osteocalcin (OCN)], bone resorption biomarkers [C-telopeptide cross-links of type I collagen (CTX) and tartrate-resistant acid phosphatase (TRAP5b)], calcium, parathyroid hormone (PTH), and vitamin D 25(OH)D increased significantly by 37.3 ± 45.2 % with training [corrected]. A repeated-measures ANOVA with time as the only factor was used to analyze data on the subset of 8 subjects who completed follow-up data collection.
resultsBAP and OCN significantly decreased by 22.8 ± 15.5% (pre 41.9 ± 10.1; post 31.7 ± 7.8 ng/ml) and 21.0 ± 23.3% (pre 15.0 ± 3.5; post 11.3 ± 2.1 ng/ml), respectively, with training, suggesting suppressed bone formation. OCN returned to baseline, while BAP remained suppressed 2-6 weeks post-training. TRAP5b significantly increased by 57.5 ± 51.6% (pre 3.0 ± 0.9; post 4.6 ± 1.4 ng/ml) from pre- to post-training, suggesting increased bone resorption, and returned to baseline 2-6 weeks post-training. PTH Increased significantly by 37.3 ± 45.2% with training. No changes in CTX, calcium, or PTH were detected.
conclusionsThese data indicate that multi-stressor military training results in increased bone resorption and suppressed bone formation, with recovery of bone metabolism 2-6 weeks after completion of training.
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Registered trials
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