ArticleBMC complementary and alternative medicine2014
Antifungal and cytotoxicity activities of the fresh xylem sap of Hymenaea courbaril L. and its major constituent fisetin.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 43 citations in OpenAlex.
- Chemical and Biological Properties of Hymenaea courbaril L.: A Review.Chemistry & biodiversity · 2026Review
- Exploring the anticancer potential of extracts and compounds from the heartwood of Cotinus coggygria Scop. wild growing in Serbia.BMC complementary medicine and therapies · 2025Article
- Fisetin-Mediated Perturbations of Membrane Permeability and Intracellular pH inJournal of microbiology and biotechnology · 2024Article
- Evaluation of the Antioxidant, Antimicrobial, and Anti-Biofilm Effects of the Stem Bark, Leaf, and Seed Extracts fromAntibiotics (Basel, Switzerland) · 2023Article
- Caryophyllene Oxide, the Active Compound Isolated from Leaves ofMolecules (Basel, Switzerland) · 2021Article
- Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources.Frontiers in pharmacology · 2021Review
- Anti-Fungal Efficacy and Mechanisms of Flavonoids.Antibiotics (Basel, Switzerland) · 2020Review
- Antimicrobial activity and chemical composition of white birch (Betula papyrifera Marshall) bark extracts.MicrobiologyOpen · 2020Article
- Phytochemical Screening of Quaking Aspen (Molecules (Basel, Switzerland) · 2018Article
- Solid-state studies and antioxidant properties of the γ-cyclodextrin·fisetin inclusion compound.Beilstein journal of organic chemistry · 2017Article
- Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models.Oncology letters · 2016Article
- Bactericidal effect of extracts and metabolites of Robinia pseudoacacia L. on Streptococcus mutans and Porphyromonas gingivalis causing dental plaque and periodontal inflammatory diseases.Molecules (Basel, Switzerland) · 2015Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe great potential of plants as Hymenaea courbaril L (jatoba) has not yet been throughly explored scientifically and therefore it is very important to investigate their pharmacological and toxicological activities to establish their real efficacy and safety. This study investigated the cytotoxicity of xylem sap of Hymenaea courbaril L and its bioactivity against the fungi Cryptococcus neoformans species complex and dermatophytes.
methodsThe fresh xylem sap of H. courbaril was filtered resulting in an insoluble brown color precipitate and was identified as fisetin. In the filtrate was identified the mixture of fisetinediol, fustin, 3-O-methyl-2,3-trans-fustin and taxifolin, which were evaluated by broth microdilution antifungal susceptibility testing against C. neoformans species complex and dermatophytes. The fresh xylem sap and fisetin were screened for cytotoxicity against the 3T3-A31 cells of Balb/c using neutral red uptake (NRU) assay.
resultsThe fresh xylem sap and the fisetin showed higher in vitro activity than the filtrate. The xylem sap of H. courbaril inhibited the growth of dermatophytes and of C. neoformans with minimal inhibition concentration (MIC) < 256 μg/mL, while the fisetin showed MIC < 128 μg/mL for these fungi. Fisetin showed lower toxicity (IC50 = 158 μg/mL) than the fresh xylem sap (IC50 = 109 μg/mL).
conclusionNaturally occurring fisetin can provide excellent starting points for clinical application and can certainly represent a therapeutic potential against fungal infections, because it showed in vitro antifungal activity and low toxicity on animal cells.
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