Evidence map›Paper›PMID 25027018›Full record

ArticleJournal of the American Heart Association2014

The impact of acute kidney injury on the long-term risk of stroke.

Vin-Cent Wu, Pei-Chen Wu, Che-Hsiung Wu, Tao-Min Huang, Chia-Hsuin Chang, Pi-Ru Tsai, Wen-Je Ko, Likwang Chen, Cheng-Yi Wang, Tzong-Shinn Chu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 7 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 7 syntheses or guidelines pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Pooled it
  8. Trial
  9. Trial
  10. Article
  11. Primary aldosteronism and long-term outcomes using PAMO definition.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  12. Article
  13. Review
  14. Article
  15. Observational
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Vin-Cent WuDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (V.C.W., C.H.C., T.S.C., K.D.W.).
Pei-Chen WuDepartment of Internal Medicine, Da-Chien General Hospital, Miaoli City, Taiwan (P.C.W.).
Che-Hsiung WuDivision of Nephrology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan (C.H.W.).
Tao-Min HuangYun-Lin Branch, National Taiwan University Hospital, Taipei, Taiwan (T.M.H.).
Chia-Hsuin ChangDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (V.C.W., C.H.C., T.S.C., K.D.W.).
Pi-Ru TsaiDepartment of Traumatology and Surgery, National Taiwan University Hospital, Taipei, Taiwan (P.R.T., W.J.K.).
Wen-Je KoDepartment of Traumatology and Surgery, National Taiwan University Hospital, Taipei, Taiwan (P.R.T., W.J.K.).
Likwang ChenInstitute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan (L.C.).
Cheng-Yi WangDepartment of Internal Medicine, and Medical Research Center, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, Xindian Dist New Taipei City, Taiwan (C.Y.W.).
Tzong-Shinn ChuDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (V.C.W., C.H.C., T.S.C., K.D.W.).
Kwan-Dun WuDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan (V.C.W., C.H.C., T.S.C., K.D.W.).
National Taiwan University Study Group on Acute Renal Failure (NSARF) Group
National Taiwan University Hospital · TWCardinal Tien Hospital · TWNational Health Research Institutes · TWTaipei Tzu Chi Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of acute kidney injury (AKI) requiring dialysis in hospitalized patients is increasing; however, information on the long-term incidence of stroke in patients surviving to discharge after recovering from AKI after dialysis has not been reported. METHODS AND

resultsPatients that survived after recovery from dialysis-requiring AKI during index hospitalizations from 1999 to 2008 were identified in nationwide administrative registries. The risk of de novo stroke and death were analyzed with time-varying Cox proportional hazard models. The results were validated by a critical care database. We enrolled 4315 patients in the AKI-recovery group (men, 57.7%; mean age, 62.8±16.8 years) and matched 4315 control subjects as the non-AKI group by propensity scores. After a median follow-up period of 3.36 years, the incident stroke rate was 15.6 per 1000 person-years. The AKI-recovery group had higher risk (hazard ratio: 1.25; P=0.037) and higher severity of stroke events than the non-AKI group, regardless of progression to subsequent chronic kidney disease. The rate of incident stroke was not statistically different in those with diabetes alone (without AKI) and in those with AKI alone (without diabetes) after hospital discharge (P=0.086). Furthermore, the risk of mortality in the AKI-recovery group was higher than in the non-AKI group (hazard ratio: 2.4; P<0.001).

conclusionsThe patients who recovered from AKI had a higher incidence of developing incident stroke and mortality than the patients without AKI, and the impact was similar to diabetes. Our results suggest that a public health initiative is needed to enhance postdischarge follow-up of renal function and to control the subsequent incidence of stroke among patients who recover from AKI after dialysis.

Indexed as

RegistriesRenal DialysisAcute Kidney InjuryAgedCase-Control StudiesFemaleHumansMaleMiddle AgedProportional Hazards ModelsRisk FactorsStrokeTaiwanacute kidney injurydialysiskidney–brain interactionmortalityrecoverystroke

Identifiers

PMID25027018
PMCPMC4310379
OpenAlexW2164353770

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.