ArticleJournal of biomedical optics2014
Target-to-background enhancement in multispectral endoscopy with background autofluorescence mitigation for quantitative molecular imaging.
Article in Journal of biomedical optics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Investigation on morphological and molecular fingerprints of penguin brain using label-free optical imaging and spectroscopic techniques.Scientific reports · 2025Article
- Improvement of the Green-Red Förster Resonance Energy Transfer-Based CaACS sensors · 2024Article
- Enhancing intraoperative tumor delineation with multispectral short-wave infrared fluorescence imaging and machine learning.Journal of biomedical optics · 2023Article
- Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes.Biogerontology · 2022Article
- Multi-Spectral Fluorescence Imaging of Colon Dysplasia InVivo Using a Multi-Spectral Endoscopy System.Translational oncology · 2019Article
- Optical Characterization of Neurosurgical Operating Microscopes: Quantitative Fluorescence and Assessment of PpIX Photobleaching.Scientific reports · 2018Article
- Scanning Fiber Endoscope Improves Detection of 5-Aminolevulinic Acid-Induced Protoporphyrin IX Fluorescence at the Boundary of Infiltrative Glioma.World neurosurgery · 2018Article
- Run-to-Run Optimization Control Within Exact Inverse Framework for Scan Tracking.Journal of dynamic systems, measurement, and control · 2017Article
- Toward real-time quantification of fluorescence molecular probes using target/background ratio for guiding biopsy and endoscopic therapy of esophageal neoplasia.Journal of medical imaging (Bellingham, Wash.) · 2017Article
- Ultraminiature optical design for multispectral fluorescence imaging endoscopes.Journal of biomedical optics · 2017Article
- Toward real-time tumor margin identification in image-guided robotic brain tumor resection.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
- Multimodal laser-based angioscopy for structural, chemical and biological imaging of atherosclerosis.Nature biomedical engineering · 2017Article
- Semi-autonomous Simulated Brain Tumor Ablation with RavenII Surgical Robot using Behavior Tree.IEEE International Conference on Robotics and Automation : ICRA : [proceedings]. IEEE International Conference on Robotics and Automation · 2015Article
- Pixel-based absorption correction for dual-tracer fluorescence imaging of receptor binding potential.Biomedical optics express · 2014Article
- Accurate three-dimensional virtual reconstruction of surgical field using calibrated trajectories of an image-guided medical robot.Journal of medical imaging (Bellingham, Wash.) · 2014Article
- Toward real-time endoscopically-guided robotic navigation based on a 3D virtual surgical field model.Proceedings of SPIE--the International Society for Optical EngineeringArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fluorescence molecular imaging with exogenous probes improves specificity for the detection of diseased tissues by targeting unambiguous molecular signatures. Additionally, increased diagnostic sensitivity is expected with the application of multiple molecular probes. We developed a real-time multispectral fluorescence-reflectance scanning fiber endoscope (SFE) for wide-field molecular imaging of fluorescent dye-labeled molecular probes at nanomolar detection levels. Concurrent multichannel imaging with the wide-field SFE also allows for real-time mitigation of the background autofluorescence (AF) signal, especially when fluorescein, a U.S. Food and Drug Administration approved dye, is used as the target fluorophore. Quantitative tissue AF was measured for the ex vivo porcine esophagus and murine brain tissues across the visible and nearinfrared spectra. AF signals were then transferred to the unit of targeted fluorophore concentration to evaluate the SFE detection sensitivity for sodium fluorescein and cyanine. Next, we demonstrated a real-time AF mitigation algorithm on a tissue phantom, which featured molecular probe targeted cells of high-grade dysplasia on a substrate containing AF species. The target-to-background ratio was enhanced by more than one order of magnitude when applying the real-time AF mitigation algorithm. Furthermore, a quantitative estimate of the fluorescein photodegradation (photobleaching) rate was evaluated and shown to be insignificant under the illumination conditions of SFE. In summary, the multichannel laser-based flexible SFE has demonstrated the capability to provide sufficient detection sensitivity, image contrast, and quantitative target intensity information for detecting small precancerous lesions in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.