ArticleThe Journal of investigative dermatology2015
Longitudinal, 3D in vivo imaging of sebaceous glands by coherent anti-stokes Raman scattering microscopy: normal function and response to cryotherapy.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Selective Cryolysis of Sebaceous Glands.The Journal of investigative dermatology · 2015Trial
- Decoding Sebaceous Gland Biology Through Experimental Models: Progress, Limitations, and Future Directions.Cells · 2026Review
- Studying Microplastic Incorporation into Corals Using CARS.Environmental science & technology · 2026Article
- The Sebaceous Gland: A Key Player in the Balance Between Homeostasis and Inflammatory Skin Diseases.Cells · 2025Review
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- Article
- High-resolution full-field optical coherence tomography microscope for the evaluation of freshly excised skin specimens during Mohs surgery: A feasibility study.Journal of biophotonics · 2024Article
- Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.Cell reports · 2023Article
- Optical Methods for Non-Invasive Determination of Skin Penetration: Current Trends, Advances, Possibilities, Prospects, and Translation into In Vivo Human Studies.Pharmaceutics · 2023Review
- Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.bioRxiv : the preprint server for biology · 2023Article
- Revisiting the Role of Local Cryotherapy for Acne Treatment: A Review and Update.Journal of clinical medicine · 2022Review
- Long-Duration and Non-Invasive Photoacoustic Imaging of Multiple Anatomical Structures in a Live Mouse Using a Single Contrast Agent.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Mapping the Lipids of Skin Sebaceous Glands and Hair Follicles by High Spatial Resolution MALDI Imaging Mass Spectrometry.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Commentary: Cryotherapy and the sebaceous glands.Indian journal of ophthalmology · 2022Article
- Portable all-fiber dual-output widely tunable light source for coherent Raman imaging.Biomedical optics express · 2019Article
- Raman Techniques: Fundamentals and Frontiers.Nanoscale research letters · 2019Review
- Optical imaging of metabolic dynamics in animals.Nature communications · 2018Article
- Working Up a Good Sweat - The Challenges of Standardising Sweat Collection for Metabolomics Analysis.The Clinical biochemist. Reviews · 2017Review
- Direct imaging of molecular symmetry by coherent anti-stokes Raman scattering.Nature communications · 2016Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Sebaceous glands perform complex functions, and they are centrally involved in the pathogenesis of acne vulgaris. Current techniques for studying sebaceous glands are mostly static in nature, whereas the gland's main function-excretion of sebum via the holocrine mechanism-can only be evaluated over time. We present a longitudinal, real-time alternative-the in vivo, label-free imaging of sebaceous glands using Coherent Anti-Stokes Raman Scattering (CARS) microscopy, which is used to selectively visualize lipids. In mouse ears, CARS microscopy revealed dynamic changes in sebaceous glands during the holocrine secretion process, as well as in response to damage to the glands caused by cooling. Detailed gland structure, plus the active migration of individual sebocytes and cohorts of sebocytes, were measured. Cooling produced characteristic changes in sebocyte structure and migration. This study demonstrates that CARS microscopy is a promising tool for studying the sebaceous gland and its associated disorders in three dimensions in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.