ArticleMarine drugs2014
Pseudaboydins A and B: novel isobenzofuranone derivatives from marine fungus Pseudallescheria boydii associated with starfish Acanthaster planci.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Bioassay-Guided Phytochemical Investigation of VietnameseMolecules (Basel, Switzerland) · 2026Article
- First environmental survey ofFrontiers in cellular and infection microbiology · 2025Article
- Cytotoxic Compounds from Marine Fungi: Sources, Structures, and Bioactivity.Marine drugs · 2024Review
- Homo/Hetero-Dimers of Aromatic Bisabolane Sesquiterpenoids with Neuroprotective Activity from the Fungus Aspergillus versicolor A18 from South China SeaMarine drugs · 2022Article
- Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches.Marine drugs · 2022Review
- Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease.Informatics in medicine unlocked · 2022Article
- Monarubins A-C from the Marine Shellfish-Associated FungusMarine drugs · 2020Article
- Exploration of Indole Alkaloids from Marine FungusMarine drugs · 2019Article
- Potential Pharmacological Resources: Natural Bioactive Compounds from Marine-Derived Fungi.Marine drugs · 2016Review
- Five New Cytotoxic Metabolites from the Marine Fungus Neosartorya pseudofischeri.Marine drugs · 2016Article
- Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.Marine drugs · 2015Article
- Exploring the chemodiversity and biological activities of the secondary metabolites from the marine fungus Neosartorya pseudofischeri.Marine drugs · 2014Article
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Authors and funding
10 authors.
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Abstract
Two novel isobenzofuranone derivatives, pseudaboydins A (1) and B (2), along with five known compounds, including (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-hydroxybenzofuran (3), (R)-2-(2-hydroxypropan-2-yl)-2,3-dihydro-5-methoxybenzofuran (4), 3,3'-dihydroxy-5,5'-dimethyldiphenyl ether (5), 3-(3-methoxy-5-methylphenoxy)-5-methylphenol (6) and (-)-regiolone (7), were isolated from the culture broth of the marine fungus, Pseudallescheria boydii, associated with the starfish, Acanthaster planci. Their structures were elucidated primarily based on NMR and MS data. The absolute configurations of 1-4 were determined by CD spectroscopy and single-crystal X-ray diffraction studies. The cytotoxic and antibacterial activities of 1-4 were evaluated. Pseudaboydin A (1) showed moderate cytotoxic activity against human nasopharyngeal carcinoma cell line HONE1, human nasopharyngeal carcinoma cell line SUNE1 and human glandular lung cancer cell line GLC82 with IC50 values of 37.1, 46.5 and 87.2 μM, respectively.
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