ArticleMarine drugs2014
Ascophyllan purified from Ascophyllum nodosum induces Th1 and Tc1 immune responses by promoting dendritic cell maturation.
Article in Marine drugs, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Trial
- Surface modification strategies for improved hemocompatibility of polymeric materials: a comprehensive review.RSC advances · 2024Review
- Polysaccharides-Naturally Occurring Immune Modulators.Polymers · 2023Review
- Article
- In Vitro and In Vivo Dendritic Cell Immune Stimulation Effect of Low Molecular Weight Fucoidan from New ZealandMarine drugs · 2022Article
- Advances in plant-derived natural products for antitumor immunotherapy.Archives of pharmacal research · 2021Review
- Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis.Algal research · 2021Article
- Polysaccharide fromMarine drugs · 2020Article
- Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica.Parasites & vectors · 2020Article
- Cancer immunotherapy using a polysaccharide fromOncoimmunology · 2020Article
- Immunostimulatory Effect of Sulfated Galactans from the Green SeaweedMarine drugs · 2020Article
- Immunoadjuvant Activity of Fucoidans from the Brown AlgaMarine drugs · 2020Article
- Diversity of bacteria populations associated with different thallus regions of the brown alga Laminaria digitata.PloS one · 2020Article
- Indocyanine green and poly I:C containing thermo-responsive liposomes used in immune-photothermal therapy prevent cancer growth and metastasis.Journal for immunotherapy of cancer · 2019Article
- Microbial Population Changes in DecayingMarine drugs · 2019Article
- Ascophyllan Induces Activation of Natural Killer Cells in Mice In Vivo and In Vitro.Marine drugs · 2019Article
- Activation of Human Dendritic Cells by Ascophyllan Purified fromMarine drugs · 2019Article
- Effects of Edible Treats ContainingFrontiers in veterinary science · 2018Article
- Article
- Ascophyllan functions as an adjuvant to promote anti-cancer effect by dendritic cell activation.Oncotarget · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Marine-derived sulfated polysaccharides have been shown to possess certain anti-virus, anti-tumor, anti-inflammatory and anti-coagulant activities. However, the in vivo immunomodulatory effects of marine-derived pure compounds have been less well characterized. In this study, we investigated the effect of ascophyllan, a sulfated polysaccharide purified from Ascophyllum nodosum, on the maturation of mouse dendritic cells (DCs) in vitro and in vivo. Ascophyllan induced up-regulation of co-stimulatory molecules and production of pro-inflammatory cytokines in bone marrow-derived DCs (BMDCs). Moreover, in vivo administration of ascophyllan promotes up-regulation of CD40, CD80, CD86, MHC class I and MHC class II and production of IL-6, IL-12 and TNF-α in spleen cDCs. Interestingly, ascophyllan induced a higher degree of co-stimulatory molecule up-regulation and pro-inflammatory cytokine production than fucoidan, a marine-derived polysaccharide with well-defined effect for promoting DC maturation. Ascophyllan also promoted the generation of IFN-γ-producing Th1 and Tc1 cells in the presence of DCs in an IL-12-dependent manner. Finally, myeloid differentiation primary response 88 (MyD88) signaling pathway was essential for DC maturation induced by ascophyllan. Taken together, these results demonstrate that ascophyllan induces DC maturation, and consequently enhances Th1 and Tc1 responses in vivo. This knowledge could facilitate the development of novel therapeutic strategies to combat infectious diseases and cancer.
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