ArticleInternational journal of molecular sciences2014
DADS suppresses human esophageal xenograft tumors through RAF/MEK/ERK and mitochondria-dependent pathways.
Article in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects.Discover oncology · 2025Review
- Diallyl disulfide in oncotherapy: molecular mechanisms and therapeutic potentials.Apoptosis : an international journal on programmed cell death · 2025Review
- The potential role of hydrogen sulfide in cancer cell apoptosis.Cell death discovery · 2024Review
- In Vitro Toxicity Studies of Bioactive Organosulfur Compounds fromFoods (Basel, Switzerland) · 2022Review
- Association and mechanism of garlic consumption with gastrointestinal cancer risk: A systematic review and meta-analysis.Oncology letters · 2022Review
- Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential.Frontiers in pharmacology · 2022Review
- Allicin in Digestive System Cancer: From Biological Effects to Clinical Treatment.Frontiers in pharmacology · 2022Review
- Long non‑coding RNA BANCR promotes proliferation, invasion and migration in esophageal squamous cell carcinoma cells via the Raf/MEK/ERK signaling pathway.Molecular medicine reports · 2021Article
- miR-574-3p inhibits proliferation and invasion in esophageal cancer by targeting FAM3C and MAPK1.The Kaohsiung journal of medical sciences · 2020Article
- Inhibition of lung cancer cells and Ras/Raf/MEK/ERK signal transduction by ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7).Respiratory research · 2019Article
- Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells.Oxidative medicine and cellular longevity · 2019Article
- Diallyl disulfide effect on the invasion and migration ability of HL-60 cells with a high expression of DJ-1 in the nucleus through the suppression of the Src signaling pathway.Oncology letters · 2018Article
- Diallyl disulphide inhibits apolipoprotein(a) expression in HepG2 cells through the MEK1-ERK1/2-ELK-1 pathway.Lipids in health and disease · 2017Article
- Spices for Prevention and Treatment of Cancers.Nutrients · 2016Review
- Effects of nitric oxide on the biological behavior of HepG2 human hepatocellular carcinoma cells.Experimental and therapeutic medicine · 2016Article
- Diallyl disulfide attenuated carbon ion irradiation-induced apoptosis in mouse testis through changing the ratio of Tap73/ΔNp73 via mitochondrial pathway.Scientific reports · 2015Article
- Curcumol Inhibits Growth and Induces Apoptosis of Colorectal Cancer LoVo Cell Line via IGF-1R and p38 MAPK Pathway.International journal of molecular sciences · 2015Article
- Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways.Cell death & disease · 2015Article
- Immunomodulation and anti-inflammatory effects of garlic compounds.Journal of immunology research · 2015Review
- Molecular science for drug development and biomedicine.International journal of molecular sciences · 2014Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diallyl disulfide (DADS) is a natural organosulfur compound isolated from garlic. DADS has various biological properties, including anticancer, antiangiogenic, and antioxidant effects. However, the anticancer mechanisms of DADS in human esophageal carcinoma have not been elucidated, especially in vivo. In this study, MTT assay showed that DADS significantly reduced cell viability in human esophageal carcinoma ECA109 cells, but was relatively less toxic in normal liver cells. The pro-apoptotic effect of DADS on ECA109 cells was detected by Annexin V-FITC/propidium iodide (PI) staining. Flow cytometry analysis showed that DADS promoted apoptosis in a dose-dependent manner and the apoptosis rate could be decreased by caspase-3 inhibitor Ac-DEVD-CHO. Xenograft study in nude mice showed that DADS treatment inhibited the growth of ECA109 tumor in both 20 and 40 mg/kg DADS groups without obvious side effects. DADS inhibited ECA109 tumor proliferation by down-regulating proliferation cell nuclear antigen (PCNA). DADS induced apoptosis by activating a mitochondria-dependent pathway with the executor of caspase-3, increasing p53 level and Bax/Bcl-2 ratio, and downregulating the RAF/MEK/ERK pathway in ECA109 xenograft tumosr. Based on studies in cell culture and animal models, the findings here indicate that DADS is an effective and safe anti-cancer agent for esophageal carcinoma.
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