Evidence map›Paper›PMID 25025658›Full record

ReviewNeuroscience and biobehavioral reviews2014

Adolescent brain maturation and smoking: what we know and where we're headed.

David M Lydon, Stephen J Wilson, Amanda Child, Charles F Geier

Open access · greenAbstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 2 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.

  1. Pooled it
  2. A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018
    Pooled it
  3. Age Moderates Smokers' Subjective Response to Very-Low Nicotine Content Cigarettes: Evidence from a Randomized Controlled Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Trial
  4. Trial
  5. Review
  6. The role of the orbitofrontal cortex in smoking cue-reactivity in onset phase of smoking behavior, a fMRI study in adolescents.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
  7. Article
  8. Something is not nothing: Hair-tested substance use and cognitive functions in a large community sample of young adults.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  9. Article
  10. Development of the Nervous System During Adolescence.Advances in experimental medicine and biology · 2026
    Review
  11. Discrimination Distress and Current Combustible and Non-combustible Tobacco Product Use Among US Youth, 2023.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

David M LydonDepartment of Human Development and Family Studies, College of Health and Human Development, The Pennsylvania State University, 315 Health and Human Development - East, University Park, PA 16802, United States. Electronic address: dml344@psu.edu.
Stephen J WilsonDepartment of Psychology, The College of the Liberal Arts, The Pennsylvania State University, 311 Moore Building, University Park, PA 16802, United States.
Amanda ChildDepartment of Human Development and Family Studies, College of Health and Human Development, The Pennsylvania State University, 315 Health and Human Development - East, University Park, PA 16802, United States.
Charles F GeierDepartment of Human Development and Family Studies, College of Health and Human Development, The Pennsylvania State University, 315 Health and Human Development - East, University Park, PA 16802, United States.
Pennsylvania State University · USUniversity of the Arts · US

Funding

Career Development Program in Women's Health Research at Penn StateK12HD055882 · NICHD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WEISMAN, CAROL S · 2007 to 2016
$4.7M
NICHD NIH HHS K12 HD055882
6 · The paper itself

Abstract

Smoking is a leading cause of mortality and morbidity worldwide. Smoking initiation often occurs during adolescence. This paper reviews and synthesizes adolescent development and nicotine dependence literatures to provide an account of adolescent smoking from onset to compulsive use. We extend neurobiological models of adolescent risk-taking, that focus on the interplay between incentive processing and cognitive control brain systems, through incorporating psychosocial and contextual factors specific to smoking, to suggest that adolescents are more vulnerable than adults to cigarette use generally, but that individual differences exist placing some adolescents at increased risk for smoking. Upon smoking, adolescents are more likely to continue smoking due to the increased positive effects induced by nicotine during this period. Continued use during adolescence, may be best understood as reflecting drug-related changes to neural systems underlying incentive processing and cognitive control, resulting in decision-making that is biased towards continued smoking. Persistent changes following nicotine exposure that may underlie continued dependence are described. We highlight ways that interventions may benefit from a consideration of cognitive-neuroscience findings.

Indexed as

AdolescentAdolescent DevelopmentAnimalsBrainDecision MakingExecutive FunctionHumansRisk-TakingSmokingSmoking PreventionTobacco Use DisorderAdolescenceCognitive controlIncentive processingNicotine dependence

Identifiers

PMID25025658
PMCPMC4451244
OpenAlexW2081496709

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.