ArticleJapanese journal of cancer research : Gann1989
Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells.
Article in Japanese journal of cancer research : Gann, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 160 citations in OpenAlex.
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- Bromodomain-containing protein 4 regulates interleukin-34 expression in mouse ovarian cancer cells.Inflammation and regeneration · 2020Article
- Comprehensive Analysis of Mouse Cancer/Testis Antigen Functions in Cancer Cells and Roles of TEKT5 in Cancer Cells and Testicular Germ Cells.Molecular and cellular biology · 2019Article
- New concepts for an old problem: the diagnosis of endometrial hyperplasia.Human reproduction update · 2017Review
- Expression of APC, β-catenin and E-cadherin in Tunisian patients with gastric adenocarcinoma: clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling.Blood · 2009Article
- Enhancer of zeste homolog 2 downregulates E-cadherin by mediating histone H3 methylation in gastric cancer cells.Cancer science · 2008Article
- DNA methylation in hepatocellular carcinoma.World journal of gastroenterology · 2008Review
- Mechanisms inactivating the gene for E-cadherin in sporadic gastric carcinomas.World journal of gastroenterology · 2006Article
- Helicobacter pylori infection in relation to E-cadherin gene promoter polymorphism and hypermethylation in sporadic gastric carcinomas.World journal of gastroenterology · 2005Article
- E-cadherin and cytokeratin subtype profiling in effusion cytology.Journal of Korean medical science · 2004Article
- MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma.Cancer science · 2003Article
- E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Co-expression of E-cadherin and alpha-catenin molecules in colorectal cancer.Surgery today · 1999Article
- A defect in cell-to-cell adhesion via integrin-fibronectin interactions in a highly metastatic tumor cell line.Japanese journal of cancer research : Gann · 1997Article
- E-cadherin relates to EGFR expression and lymph node metastasis in primary breast carcinoma.British journal of cancer · 1996Article
- Inhibition of growth and metastasis of ovarian carcinoma by administering a drug capable of interfering with vascular endothelial growth factor activity.Japanese journal of cancer research : Gann · 1996Article
- Restricted expression of galactose/N-acetylgalactosamine-specific macrophage C-type lectin to connective tissue and to metastatic lesions in mouse lung.Immunology · 1995Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E-Cadherin is a member of the cadherin family, which plays a key role in intercellular adhesion in various tumors as well as in normal tissues. Here, we examined the expression of this adhesion molecule in a murine ovarian tumor line OV2944, whose sublines show different degrees of spontaneous metastasis from subcutaneous sites; sublines LM-1 and LM-3 exhibit a low metastatic activity but a variant subline HM-1 has a high metastatic activity. When the expression of E-cadherin in these cells was examined by immunoblot analysis, the highly metastatic HM-1 cells was found to express an extremely small amount of this molecule, as compared with a high level of E-cadherin expression in the weakly metastatic LM-1 and LM-3 cells. Northern blot analysis showed that the amount of tanscripts from the E-cadherin gene is proportional to the amount of proteins detected in these cells. Immunofluorescence staining revealed that cells of the highly metastatic line were heterogeneous, that is, their cultures contained both E-cadherin-positive and negative cells. In contrast, cells of the weakly metastatic lines homogeneously expressed E-cadherin. When the highly metastatic line was subcloned, all the subclones consisted of E-cadherin-positive and negative cells. These results suggest that the expression of E-cadherin gene is not stably controlled in the highly metastatic line.
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