ArticlePloS one2014
Why do sleeping nematodes adopt a hockey-stick-like posture?
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
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- Sleep Analysis in AdultThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A microfluidic-induced C. elegans sleep state.Nature communications · 2019Article
- Automated detection and manipulation of sleep in C. elegans reveals depolarization of a sleep-active neuron during mechanical stimulation-induced sleep deprivation.Scientific reports · 2018Article
- On-chip functional neuroimaging with mechanical stimulation in Caenorhabditis elegans larvae for studying development and neural circuits.Lab on a chip · 2018Article
- The Sleep in Caenorhabditis elegans: What We Know Until Now.Molecular neurobiology · 2018Review
- Distinct unfolded protein responses mitigate or mediate effects of nonlethal deprivation of C. elegans sleep in different tissues.BMC biology · 2017Article
- Food responsiveness regulates episodic behavioral states inJournal of neurophysiology · 2017Article
- Analysis of the NK2 homeobox geneeLife · 2017Article
- NemaCount: quantification of nematode chemotaxis behavior in a browser.Invertebrate neuroscience : IN · 2016Article
- Review
- Call it Worm Sleep.Trends in neurosciences · 2016Review
- Caenorhabditis elegans exhibit a coupling between the defecation motor program and directed locomotion.Scientific reports · 2015Article
- Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics.Journal of neurogeneticsArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A characteristic posture is considered one of the behavioral hallmarks of sleep, and typically includes functional features such as support for the limbs and shielding of sensory organs. The nematode C. elegans exhibits a sleep-like state during a stage termed lethargus, which precedes ecdysis at the transition between larval stages. A hockey-stick-like posture is commonly observed during lethargus. What might its function be? It was previously noted that during lethargus, C. elegans nematodes abruptly rotate about their longitudinal axis. Plausibly, these "flips" facilitate ecdysis by assisting the disassociation of the old cuticle from the new one. We found that body-posture during lethargus was established using a stereotypical motor program and that body bends during lethargus quiescence were actively maintained. Moreover, flips occurred almost exclusively when the animals exhibited a single body bend, preferentially in the anterior or mid section of the body. We describe a simple biomechanical model that imposes the observed lengths of the longitudinally directed body-wall muscles on an otherwise passive elastic rod. We show that this minimal model is sufficient for generating a rotation about the anterior-posterior body axis. Our analysis suggests that posture during lethargus quiescence may serve a developmental role in facilitating flips and that the control of body wall muscles in anterior and posterior body regions are distinct.
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