ArticleEvidence-based complementary and alternative medicine : eCAM2014
The effect of scalp point cluster-needling on learning and memory function and neurotransmitter levels in rats with vascular dementia.
Article in Evidence-based complementary and alternative medicine : eCAM, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Effect of acupuncture on monoaminergic neurotransmitters in animal models of vascular dementia: a preclinical systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Efficacy of acupuncture in animal models of vascular dementia: A systematic review and network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Effects of acupuncture on vascular dementia (VD) animal models: a systematic review and meta-analysis.BMC complementary and alternative medicine · 2018Pooled it
- Effects of Acupuncture on Vascular Cognitive Impairment with No Dementia: A Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2021Trial
- The effects and mechanisms of acupuncture for post-stroke cognitive impairment: progress and prospects.Frontiers in neuroscience · 2023Review
- Acupuncture Therapy on Dementia: Explained with an Integrated Analysis on Therapeutic Targets and Associated Mechanisms.Journal of Alzheimer's disease : JAD · 2023Article
- Standardizing therapeutic parameters of acupuncture in vascular dementia rats.Brain and behavior · 2020Article
- Effect of Selective 5-HT6R Agonist on Expression of 5-HT Receptor and Neurotransmitter in Vascular Dementia Rats.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Protective effects of tao-Hong-si-wu decoction on memory impairment and hippocampal damage in animal model of vascular dementia.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Sino-Austrian High-Tech Acupuncture Network-Annual Report 2014.Medicines (Basel, Switzerland) · 2014Article
- Integrative neurobiological mechanisms of acupuncture in post-stroke cognitive impairment: from neurotransmission to brain network remodeling.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We observed the effect of scalp point cluster-needling treatment on learning and memory function and neurotransmitter levels in rats with vascular dementia (VD). Permanent ligation of the bilateral carotid arteries was used to create the VD rat model. A Morris water maze was used to measure the rats' learning and memory function, and the changes in neurotransmitter levels in the rats' hippocampus were analyzed. The results show that scalp point cluster-needling can increase the VD rat model's learning and memory score. The VD rat model's learning and memory score was significantly different when compared with that of the sham operation group (P < 0.05). Hippocampal acetylcholine (ACh), dopamine (DA), and 5-hydroxytryptamine (5-HT) concentrations significantly decreased in the rat model. Compared with the model group, the scalp point cluster-needling group's ACh concentration markedly increased and DA and 5-HT levels increased as well. In conclusion, scalp point cluster-needling can improve learning and memory function in VD rats, and its function may be related to an increase in neurotransmitter release.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.