ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2014
Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Sleep features and the risk of type 2 diabetes mellitus: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Circadian rhythm disrupting behaviours and cancer outcomes in breast cancer survivors: a systematic review.Breast cancer research and treatment · 2023Pooled it
- Association between sleep duration and cardiac structure in youths at risk for metabolic syndrome.Scientific reports · 2016Trial
- Relationship Between the "Life's Essential 8" Lifestyle Metrics and Serum High-Sensitivity C-Reactive Protein Levels in South Korea.Life (Basel, Switzerland) · 2026Article
- Chronic REM Sleep Deprivation Induces Metabolic and Neurotoxic Alterations Associated with Affective and Cognitive Deficit in Male Wistar Rats: Involvement of HPA Axis, Cholinergic, Inflammatory, and Oxidative Stress Pathways.Neurochemical research · 2026Article
- Chronic Insomnia and Stroke Risk-A Real Bidirectional Issue.Life (Basel, Switzerland) · 2025Review
- Association of sleep duration with hypertension in young and middle-aged adults: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2025Review
- Wearable-derived short sleep duration is associated with higher C-reactive protein in a placebo-controlled vaccine trial among young adults.Scientific reports · 2025Article
- Distinct Sleep Quality Profiles and Their Varying Levels of Stigma Among Patients Undergoing Maintenance Hemodialysis: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2025Article
- Vitamin D insufficiency and sleep disturbances in children with ADHD: a case-control study.Frontiers in psychiatry · 2025Article
- Sleep, Fatigue, and Inflammatory Biomarkers in Older Adults with Chronic Venous Leg Ulcers Receiving Intensive Outpatient Wound Care.Advances in wound care · 2024Article
- The association of sleep duration with the risk of chronic kidney disease: a systematic review and meta-analysis.Clinical kidney journal · 2024Article
- The effect of sleep and its restriction on selected inflammatory parameters.Scientific reports · 2024Article
- Elevated oxidative stress biomarkers in adults with segmented sleep patterns.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Associations between sleep duration, sleep disturbance and cardiovascular disease biomarkers among adults in the United States.BMC public health · 2024Article
- Association between sleep problems and functional disability in community-dwelling older adults.BMC geriatrics · 2024Article
- C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.Diseases (Basel, Switzerland) · 2023Review
- Circadian disruption and psychostimulants dysregulates plasma acute-phase proteins and circulating cell-free mitochondrial DNA.Brain, behavior, & immunity - health · 2023Article
- The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency.Healthcare (Basel, Switzerland) · 2023Article
- Short sleep duration associated with the incidence of cardio-cerebral vascular disease: a prospective cohort study in Shanghai, China.BMC cardiovascular disorders · 2023Article
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Abstract
backgroundElevated plasma levels of high-sensitivity C-reactive protein (hs-CRP) have been associated with increased adverse health outcomes. The aim of this study was to investigate the association of sleep duration with risk of elevated hs-CRP levels in Taiwanese adults.
methodsWe examined the association between sleep duration and hs-CRP in 353 healthy adults recruited from the physical examination center at a regional hospital in southern Taiwan. Elevated hs-CRP was defined as a plasma level ≥ 0.20 mg/dL. Short sleep duration was defined as ≤ 5.5 h per day. Multiple logistic regression analysis was used to assess the association of short duration of sleep with elevated hs-CRP levels.
resultsIn this study, short duration of sleep (odds ratio [OR] = 2.20; 95% confidence interval [CI]: 1.11-4.30), aged 70 years or older (OR = 4.58; 95% CI: 1.70-12.66), menopause (OR = 2.81; 95% CI: 1.52-5.3), higher heart rate (OR = 1.38; 95% CI: 1.10-1.75), higher body mass index (OR = 1.20; 95% CI: 1.09-1.34), higher white blood cell count (OR = 1.38; 95% CI: 1.14-1.66), and higher uric acid level (OR = 1.31; 95% CI: 1.06-1.63) were significantly associated with an increased risk of elevated hs-CRP levels.
conclusionsIn this study of healthy Taiwanese adults, short duration of sleep was significantly associated with elevated hs-CRP levels. Activation of pro-inflammatory pathways might represent a mechanism by which short sleep duration affects health.
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