Evidence map›Paper›PMID 25024425›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2014

Preclinical evaluation of robotic-assisted sentinel lymph node fluorescence imaging.

Michael A Liss, Salman Farshchi-Heydari, Zhengtao Qin, Sean A Hickey, David J Hall, Christopher J Kane, David R Vera

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Fluorescence-Based Molecular Imaging of Porcine Urinary Bladder Sentinel Lymph Nodes.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017
    Article
  6. Sentinel lymph node biopsy in bladder cancer: Systematic review and technology update.Indian journal of urology : IJU : journal of the Urological Society of India
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael A LissDepartment of Urology, University of California, San Diego, La Jolla, California UCSD Moores Cancer Center. University of California, San Diego, La Jolla, California.
Salman Farshchi-HeydariDepartment of Radiology, University of California, San Diego, La Jolla, California UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, California.
Zhengtao QinDepartment of Radiology, University of California, San Diego, La Jolla, California UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, California Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California; and.
Sean A HickeyDepartment of Surgery, University of California, San Diego, La Jolla, California.
David J HallDepartment of Radiology, University of California, San Diego, La Jolla, California UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, California.
Christopher J KaneDepartment of Urology, University of California, San Diego, La Jolla, California UCSD Moores Cancer Center. University of California, San Diego, La Jolla, California Department of Surgery, University of California, San Diego, La Jolla, California.
David R VeraUCSD Moores Cancer Center. University of California, San Diego, La Jolla, California Department of Radiology, University of California, San Diego, La Jolla, California UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, California Department of Surgery, University of California, San Diego, La Jolla, California dvera@ucsd.edu.

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Targeted Smart Nanoplatforms for Multimode ImagingP50CA128346 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STUPACK, DWAYNE G. · 2008 to 2012
$6.9M
NCI NIH HHS P30 CA023100NCI NIH HHS P50 CA128346
6 · The paper itself

Abstract

unlabelledAn ideal substance to provide convenient and accurate targeting for sentinel lymph node (SLN) mapping during robotic-assisted surgery has yet to be found. We used an animal model to determine the ability of the FireFly camera system to detect fluorescent SLNs after administration of a dual-labeled molecular imaging agent.

methodsWe injected the footpads of New Zealand White rabbits with 1.7 or 8.4 nmol of tilmanocept labeled with (99m)Tc and a near-infrared fluorophore, IRDye800CW. One and 36 h after injection, popliteal lymph nodes, representing the SLNs, were dissected with the assistance of the FireFly camera system, a fluorescence-capable endoscopic imaging system. After excision of the paraaortic lymph nodes, which represented non-SLNs, we assayed all lymph nodes for radioactivity and fluorescence intensity.

resultsFluorescence within all popliteal lymph nodes was easily detected by the FireFly camera system. Fluorescence within the lymph channel could be imaged during the 1-h studies. When compared with the paraaortic lymph nodes, the popliteal lymph nodes retain greater than 95% of the radioactivity at both 1 and 36 h after injection. At both doses (1.7 and 8.4 nmol), the popliteal nodes had higher (P < 0.050) optical fluorescence intensity than the paraaortic nodes at the 1- and 36-h time points.

conclusionThe FireFly camera system can easily detect tilmanocept labeled with a near-infrared fluorophore at least 36 h after administration. This ability will permit image acquisition and subsequent verification of fluorescence-labeled SLNs during robotic-assisted surgery.

Indexed as

AnimalsLymph Node ExcisionRabbitsRoboticsSentinel Lymph Node BiopsySpectrometry, Fluorescencefluorescent tilmanoceptrobotic-assisted surgerysentinel lymph node mapping

Identifiers

PMID25024425
PMCPMC4350927

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.